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Alpha-chemokine receptor blockade reduces high mobility group box 1 protein-induced lung inflammation and injury and improves survival in sepsis.
Lin X, Yang H, Sakuragi T, Hu M, Mantell LL, Hayashi S, Al-Abed Y, Tracey KJ, Ulloa L, Miller EJ. Lin X, et al. Among authors: yang h. Am J Physiol Lung Cell Mol Physiol. 2005 Oct;289(4):L583-90. doi: 10.1152/ajplung.00091.2005. Epub 2005 Jun 3. Am J Physiol Lung Cell Mol Physiol. 2005. PMID: 15937067 Free article.
The selective alpha7 agonist GTS-21 attenuates cytokine production in human whole blood and human monocytes activated by ligands for TLR2, TLR3, TLR4, TLR9, and RAGE.
Rosas-Ballina M, Goldstein RS, Gallowitsch-Puerta M, Yang L, Valdés-Ferrer SI, Patel NB, Chavan S, Al-Abed Y, Yang H, Tracey KJ. Rosas-Ballina M, et al. Among authors: yang l, yang h. Mol Med. 2009 Jul-Aug;15(7-8):195-202. doi: 10.2119/molmed.2009.00039. Epub 2009 Apr 27. Mol Med. 2009. PMID: 19593403 Free PMC article.
Inhibition of high-mobility group box 1 protein (HMGB1) enhances bacterial clearance and protects against Pseudomonas Aeruginosa pneumonia in cystic fibrosis.
Entezari M, Weiss DJ, Sitapara R, Whittaker L, Wargo MJ, Li J, Wang H, Yang H, Sharma L, Phan BD, Javdan M, Chavan SS, Miller EJ, Tracey KJ, Mantell LL. Entezari M, et al. Among authors: yang h. Mol Med. 2012 May 9;18(1):477-85. doi: 10.2119/molmed.2012.00024. Mol Med. 2012. PMID: 22314397 Free PMC article.
Novel role of PKR in inflammasome activation and HMGB1 release.
Lu B, Nakamura T, Inouye K, Li J, Tang Y, Lundbäck P, Valdes-Ferrer SI, Olofsson PS, Kalb T, Roth J, Zou Y, Erlandsson-Harris H, Yang H, Ting JP, Wang H, Andersson U, Antoine DJ, Chavan SS, Hotamisligil GS, Tracey KJ. Lu B, et al. Among authors: yang h. Nature. 2012 Aug 30;488(7413):670-4. doi: 10.1038/nature11290. Nature. 2012. PMID: 22801494 Free PMC article.
High Mobility Group Box-1 mediates hyperoxia-induced impairment of Pseudomonas aeruginosa clearance and inflammatory lung injury in mice.
Patel VS, Sitapara RA, Gore A, Phan B, Sharma L, Sampat V, Li JH, Yang H, Chavan SS, Wang H, Tracey KJ, Mantell LL. Patel VS, et al. Among authors: yang h. Am J Respir Cell Mol Biol. 2013 Mar;48(3):280-7. doi: 10.1165/rcmb.2012-0279OC. Epub 2012 Oct 18. Am J Respir Cell Mol Biol. 2013. PMID: 23087050 Free PMC article.
JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation.
Lu B, Antoine DJ, Kwan K, Lundbäck P, Wähämaa H, Schierbeck H, Robinson M, Van Zoelen MA, Yang H, Li J, Erlandsson-Harris H, Chavan SS, Wang H, Andersson U, Tracey KJ. Lu B, et al. Among authors: yang h. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3068-73. doi: 10.1073/pnas.1316925111. Epub 2014 Jan 27. Proc Natl Acad Sci U S A. 2014. PMID: 24469805 Free PMC article.
Inhibition of extracellular HMGB1 attenuates hyperoxia-induced inflammatory acute lung injury.
Entezari M, Javdan M, Antoine DJ, Morrow DM, Sitapara RA, Patel V, Wang M, Sharma L, Gorasiya S, Zur M, Wu W, Li J, Yang H, Ashby CR, Thomas D, Wang H, Mantell LL. Entezari M, et al. Among authors: yang h. Redox Biol. 2014 Jan 20;2:314-22. doi: 10.1016/j.redox.2014.01.013. eCollection 2014. Redox Biol. 2014. PMID: 24563849 Free PMC article.
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