Yang G - Search Results

1

Design and discovery of new selective and potent VEGF receptor 2 tyrosine kinase inhibitors.

Hou F, Yao Y, Wei Y, Wang Y, Cao Y, Liu X, Zheng L, Zhang Q, Jiao Y, Chen Y, Meng Y, Sun Y, Wu Y, Wang J, Wang J, Wu Z, Zhang K, Wei M, Yang G. Hou F, et al. Among authors: yang g. Bioorg Med Chem. 2023 Aug 15;91:117404. doi: 10.1016/j.bmc.2023.117404. Epub 2023 Jul 3. Bioorg Med Chem. 2023. PMID: 37429211

2

Structure optimization and discovery of novel compound for the treatment of insertion mutations within exon 20 of EGFR and HER2.

Cui Y, Wang R, Wei Y, Hou F, Li H, Jiang Y, Sun Y, Fu S, Zuo L, Wang X, Li M, Li J, Liu N, Zhang K, Wei M, Yang G. Cui Y, et al. Among authors: yang g. Bioorg Med Chem. 2023 Mar 1;81:117202. doi: 10.1016/j.bmc.2023.117202. Epub 2023 Feb 11. Bioorg Med Chem. 2023. PMID: 36804726

3

Design, synthesis and evaluation of a pyrazolo[3,4-d]pyrimidine derivative as a novel and potent TGFβ1R1 inhibitor.

Wang Y, Liu Y, Zhang Y, Zhang Z, Xu L, Wang J, Yang Y, Hu B, Yao Y, Wei M, Wang J, Tang B, Zhang K, Liu S, Yang G. Wang Y, et al. Among authors: yang g, yang y. Eur J Med Chem. 2024 May 5;271:116395. doi: 10.1016/j.ejmech.2024.116395. Epub 2024 Apr 12. Eur J Med Chem. 2024. PMID: 38626523

4

Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors.

Cheng JF, Mak CC, Huang Y, Penuliar R, Nishimoto M, Zhang L, Chen M, Wallace D, Arrhenius T, Chu D, Yang G, Barbosa M, Barr R, Dyck JR, Lopaschuk GD, Nadzan AM. Cheng JF, et al. Among authors: yang g. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3484-8. doi: 10.1016/j.bmcl.2006.03.100. Epub 2006 Apr 27. Bioorg Med Chem Lett. 2006. PMID: 16644218

5

Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore.

Marino JP Jr, Fisher PW, Hofmann GA, Kirkpatrick RB, Janson CA, Johnson RK, Ma C, Mattern M, Meek TD, Ryan MD, Schulz C, Smith WW, Tew DG, Tomazek TA Jr, Veber DF, Xiong WC, Yamamoto Y, Yamashita K, Yang G, Thompson SK. Marino JP Jr, et al. Among authors: yang g. J Med Chem. 2007 Aug 9;50(16):3777-85. doi: 10.1021/jm061182w. Epub 2007 Jul 18. J Med Chem. 2007. PMID: 17636946

6

Synthesis and structure-activity relationship of 4-(2-aryl-cyclopropylamino)-quinoline-3-carbonitriles as EGFR tyrosine kinase inhibitors.

Pannala M, Kher S, Wilson N, Gaudette J, Sircar I, Zhang SH, Bakhirev A, Yang G, Yuen P, Gorcsan F, Sakurai N, Barbosa M, Cheng JF. Pannala M, et al. Among authors: yang g. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5978-82. doi: 10.1016/j.bmcl.2007.07.071. Epub 2007 Aug 21. Bioorg Med Chem Lett. 2007. PMID: 17827009

7

Discovery of Linvencorvir (RG7907), a Hepatitis B Virus Core Protein Allosteric Modulator, for the Treatment of Chronic HBV Infection.

Zhang W, Guo L, Liu H, Wu G, Shi H, Zhou M, Zhang Z, Kou B, Hu T, Zhou Z, Xu Z, Zhou X, Zhou Y, Tian X, Yang G, Young JAT, Qiu H, Ottaviani G, Xie J, Mayweg AV, Shen HC, Zhu W. Zhang W, et al. Among authors: yang g. J Med Chem. 2023 Mar 23;66(6):4253-4270. doi: 10.1021/acs.jmedchem.3c00173. Epub 2023 Mar 10. J Med Chem. 2023. PMID: 36896968

8

Discovery of 4,5,6,7-Tetrahydropyrazolo[1.5-a]pyrizine Derivatives as Core Protein Allosteric Modulators (CpAMs) for the Inhibition of Hepatitis B Virus.

Kou B, Zhang Z, Han X, Zhou Z, Xu Z, Zhou X, Shen F, Zhou Y, Tian X, Yang G, Young JAT, Qiu H, Ottaviani G, Mayweg A, Zhu W, Shen HC, Liu H, Hu T. Kou B, et al. Among authors: yang g. J Med Chem. 2023 Oct 26;66(20):14116-14132. doi: 10.1021/acs.jmedchem.3c01145. Epub 2023 Oct 6. J Med Chem. 2023. PMID: 37801325

9

Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents.

Cheng JF, Huang Y, Penuliar R, Nishimoto M, Liu L, Arrhenius T, Yang G, O'leary E, Barbosa M, Barr R, Dyck JR, Lopaschuk GD, Nadzan AM. Cheng JF, et al. Among authors: yang g. J Med Chem. 2006 Jul 13;49(14):4055-8. doi: 10.1021/jm0605029. J Med Chem. 2006. PMID: 16821767

10

Pyridine-derived γ-secretase modulators.

Wan Z, Hall A, Sang Y, Xiang JN, Yang E, Smith B, Harrison DC, Yang G, Yu H, Price HS, Wang J, Hawkins J, Lau LF, Johnson MR, Li T, Zhao W, Mitchell WL, Su X, Zhang X, Zhou Y, Jin Y, Tong Z, Cheng Z, Hussain I, Elliott JD, Matsuoka Y. Wan Z, et al. Among authors: yang e, yang g. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4832-5. doi: 10.1016/j.bmcl.2011.06.042. Epub 2011 Jun 17. Bioorg Med Chem Lett. 2011. PMID: 21742495

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