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Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate.
J Med Chem. 2018 Feb 8;61(3):1001-1018. doi: 10.1021/acs.jmedchem.7b01466. Epub 2018 Jan 16.
J Med Chem. 2018.
PMID: 29293004
Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor.
Helal CJ, Arnold EP, Boyden TL, Chang C, Chappie TA, Fennell KF, Forman MD, Hajos M, Harms JF, Hoffman WE, Humphrey JM, Kang Z, Kleiman RJ, Kormos BL, Lee CW, Lu J, Maklad N, McDowell L, Mente S, O'Connor RE, Pandit J, Piotrowski M, Schmidt AW, Schmidt CJ, Ueno H, Verhoest PR, Yang EX.
Helal CJ, et al. Among authors: yang ex.
J Med Chem. 2017 Jul 13;60(13):5673-5698. doi: 10.1021/acs.jmedchem.7b00397. Epub 2017 Jun 16.
J Med Chem. 2017.
PMID: 28574706
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Late-Stage Microsomal Oxidation Reduces Drug-Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189.
Stepan AF, Tran TP, Helal CJ, Brown MS, Chang C, O'Connor RE, De Vivo M, Doran SD, Fisher EL, Jenkinson S, Karanian D, Kormos BL, Sharma R, Walker GS, Wright AS, Yang EX, Brodney MA, Wager TT, Verhoest PR, Obach RS.
Stepan AF, et al. Among authors: yang ex.
ACS Med Chem Lett. 2018 Jan 4;9(2):68-72. doi: 10.1021/acsmedchemlett.7b00343. eCollection 2018 Feb 8.
ACS Med Chem Lett. 2018.
PMID: 29456790
Free PMC article.
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Correction to Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor.
Helal CJ, Arnold EP, Boyden TL, Chang C, Chappie TA, Fennell KF, Forman MD, Hajos M, Harms JF, Hoffman WE, Humphrey JM, Kang Z, Kleiman RJ, Kormos BL, LaChapelle EA, Lee CW, Lu J, Maklad N, McDowell L, Mente S, O'Connor RE, Pandit J, Piotrowski M, Schmidt AW, Schmidt CJ, Ueno H, Verhoest PR, Yang EX.
Helal CJ, et al. Among authors: yang ex.
J Med Chem. 2018 Apr 26;61(8):3753. doi: 10.1021/acs.jmedchem.8b00475. Epub 2018 Apr 6.
J Med Chem. 2018.
PMID: 29624389
No abstract available.
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Secondary amine analogues of 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid esters and N-norcocaine exhibit enhanced affinity for serotonin and norepinephrine transporters.
Boja JW, Kuhar MJ, Kopajtic T, Yang E, Abraham P, Lewin AH, Carroll FI.
Boja JW, et al.
J Med Chem. 1994 Apr 15;37(8):1220-3. doi: 10.1021/jm00034a021.
J Med Chem. 1994.
PMID: 8164265
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Taste contribution of (R)-strombine to dried scallop.
Starkenmann C, Cayeux I, Decorzant E, Yang EX, Niclass Y, Nicolas L.
Starkenmann C, et al. Among authors: yang ex.
J Agric Food Chem. 2009 Sep 9;57(17):7938-43. doi: 10.1021/jf901553e.
J Agric Food Chem. 2009.
PMID: 19663385
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[ISSR-PCR analysis in different species and populations of Rhizoma Curcumae].
Wang XH, Tang XC, Yang EX, Liu DJ, Li M, Li XK.
Wang XH, et al. Among authors: yang ex.
Zhongguo Zhong Yao Za Zhi. 2008 Sep;33(18):2037-40.
Zhongguo Zhong Yao Za Zhi. 2008.
PMID: 19160778
Chinese.
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