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Structure, function and drug discovery of GPCR signaling.
Cheng L, Xia F, Li Z, Shen C, Yang Z, Hou H, Sun S, Feng Y, Yong X, Tian X, Qin H, Yan W, Shao Z. Cheng L, et al. Among authors: yan w. Mol Biomed. 2023 Dec 4;4(1):46. doi: 10.1186/s43556-023-00156-w. Mol Biomed. 2023. PMID: 38047990 Free PMC article. Review.
Molecular mechanism of agonism and inverse agonism in ghrelin receptor.
Qin J, Cai Y, Xu Z, Ming Q, Ji SY, Wu C, Zhang H, Mao C, Shen DD, Hirata K, Ma Y, Yan W, Zhang Y, Shao Z. Qin J, et al. Among authors: yan w. Nat Commun. 2022 Jan 13;13(1):300. doi: 10.1038/s41467-022-27975-9. Nat Commun. 2022. PMID: 35027551 Free PMC article.
Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1.
Yang X, Wang X, Xu Z, Wu C, Zhou Y, Wang Y, Lin G, Li K, Wu M, Xia A, Liu J, Cheng L, Zou J, Yan W, Shao Z, Yang S. Yang X, et al. Among authors: yan w. Nat Chem Biol. 2022 Aug;18(8):831-840. doi: 10.1038/s41589-022-01038-y. Epub 2022 May 30. Nat Chem Biol. 2022. PMID: 35637350
Allosteric modulation of G protein-coupled receptor signaling.
Shen S, Zhao C, Wu C, Sun S, Li Z, Yan W, Shao Z. Shen S, et al. Among authors: yan w. Front Endocrinol (Lausanne). 2023 Feb 16;14:1137604. doi: 10.3389/fendo.2023.1137604. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 36875468 Free PMC article. Review.
Cryo-EM structures of human GPR34 enable the identification of selective antagonists.
Xia A, Yong X, Zhang C, Lin G, Jia G, Zhao C, Wang X, Hao Y, Wang Y, Zhou P, Yang X, Deng Y, Wu C, Chen Y, Zhu J, Tang X, Liu J, Zhang S, Zhang J, Xu Z, Hu Q, Zhao J, Yue Y, Yan W, Su Z, Wei Y, Zhou R, Dong H, Shao Z, Yang S. Xia A, et al. Among authors: yan w. Proc Natl Acad Sci U S A. 2023 Sep 26;120(39):e2308435120. doi: 10.1073/pnas.2308435120. Epub 2023 Sep 21. Proc Natl Acad Sci U S A. 2023. PMID: 37733739 Free PMC article.
Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z. Xu Z, et al. Among authors: yan w. Nature. 2023 Dec;624(7992):672-681. doi: 10.1038/s41586-023-06804-z. Epub 2023 Nov 7. Nature. 2023. PMID: 37935376
7,953 results