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A novel screening approach comparing kinase activity of small molecule inhibitors with similar molecular structures and distinct biologic effects in triple-negative breast cancer to identify targetable signaling pathways.
Matossian MD, Burks HE, Elliott S, Hoang VT, Zuercher WJ, Wells C, Drewry DH, Kapadia N, Chang T, Yan T, Windsor GO, Nguyen K, Fang F, Nephew KP, Buechlein A, Rusch DB, Sabol RA, Ucar DA, Zabaleta J, Miele L, Bunnell BA, Collins-Burow BM, Burow ME. Matossian MD, et al. Anticancer Drugs. 2020 Sep;31(8):759-775. doi: 10.1097/CAD.0000000000000962. Anticancer Drugs. 2020. PMID: 32796402 Free PMC article.
NEK5 activity regulates the mesenchymal and migratory phenotype in breast cancer cells.
Matossian MD, Elliott S, Van Hoang T, Burks HE, Wright MK, Alzoubi MS, Yan T, Chang T, Wathieu H, Windsor GO, Hartono AB, Lee S, Zuercher WJ, Drewry DH, Wells C, Kapadia N, Buechlein A, Fang F, Nephew KP, Collins-Burow BM, Burow ME. Matossian MD, et al. Breast Cancer Res Treat. 2021 Aug;189(1):49-61. doi: 10.1007/s10549-021-06295-4. Epub 2021 Jul 1. Breast Cancer Res Treat. 2021. PMID: 34196902
Oncogenic signaling of MEK5-ERK5.
Hoang VT, Yan TJ, Cavanaugh JE, Flaherty PT, Beckman BS, Burow ME. Hoang VT, et al. Among authors: yan tj. Cancer Lett. 2017 Apr 28;392:51-59. doi: 10.1016/j.canlet.2017.01.034. Epub 2017 Jan 30. Cancer Lett. 2017. PMID: 28153789 Free PMC article. Review.
Evaluation of the Quality Blue Primary Care program on health outcomes.
Shi Q, Yan TJ, Lee P, Murphree P, Yuan X, Shao H, Bestermann WH, Loupe S, Cantrell D, Carmouche D, Strapp J, Shi L. Shi Q, et al. Among authors: yan tj. Am J Manag Care. 2017 Dec 1;23(12):e402-e408. Am J Manag Care. 2017. PMID: 29261245 Free article.