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Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms.
Beltra JC, Manne S, Abdel-Hakeem MS, Kurachi M, Giles JR, Chen Z, Casella V, Ngiow SF, Khan O, Huang YJ, Yan P, Nzingha K, Xu W, Amaravadi RK, Xu X, Karakousis GC, Mitchell TC, Schuchter LM, Huang AC, Wherry EJ. Beltra JC, et al. Among authors: yan p. Immunity. 2020 May 19;52(5):825-841.e8. doi: 10.1016/j.immuni.2020.04.014. Epub 2020 May 11. Immunity. 2020. PMID: 32396847 Free PMC article.
TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion.
Khan O, Giles JR, McDonald S, Manne S, Ngiow SF, Patel KP, Werner MT, Huang AC, Alexander KA, Wu JE, Attanasio J, Yan P, George SM, Bengsch B, Staupe RP, Donahue G, Xu W, Amaravadi RK, Xu X, Karakousis GC, Mitchell TC, Schuchter LM, Kaye J, Berger SL, Wherry EJ. Khan O, et al. Among authors: yan p. Nature. 2019 Jul;571(7764):211-218. doi: 10.1038/s41586-019-1325-x. Epub 2019 Jun 17. Nature. 2019. PMID: 31207603 Free PMC article.
A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma.
Huang AC, Orlowski RJ, Xu X, Mick R, George SM, Yan PK, Manne S, Kraya AA, Wubbenhorst B, Dorfman L, D'Andrea K, Wenz BM, Liu S, Chilukuri L, Kozlov A, Carberry M, Giles L, Kier MW, Quagliarello F, McGettigan S, Kreider K, Annamalai L, Zhao Q, Mogg R, Xu W, Blumenschein WM, Yearley JH, Linette GP, Amaravadi RK, Schuchter LM, Herati RS, Bengsch B, Nathanson KL, Farwell MD, Karakousis GC, Wherry EJ, Mitchell TC. Huang AC, et al. Among authors: yan pk. Nat Med. 2019 Mar;25(3):454-461. doi: 10.1038/s41591-019-0357-y. Epub 2019 Feb 25. Nat Med. 2019. PMID: 30804515 Free PMC article. Clinical Trial.
Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics.
Giles JR, Ngiow SF, Manne S, Baxter AE, Khan O, Wang P, Staupe R, Abdel-Hakeem MS, Huang H, Mathew D, Painter MM, Wu JE, Huang YJ, Goel RR, Yan PK, Karakousis GC, Xu X, Mitchell TC, Huang AC, Wherry EJ. Giles JR, et al. Among authors: yan pk. Nat Immunol. 2022 Nov;23(11):1600-1613. doi: 10.1038/s41590-022-01338-4. Epub 2022 Oct 21. Nat Immunol. 2022. PMID: 36271148 Free PMC article.
Microglia-targeted inhibition of miR-17 via mannose-coated lipid nanoparticles improves pathology and behavior in a mouse model of Alzheimer's disease.
Badr A, Daily KP, Eltobgy M, Estfanous S, Tan MH, Chun-Tien Kuo J, Whitham O, Carafice C, Gupta G, Amer HM, Shamseldin MM, Yousif A, Deems NP, Fitzgerald J, Yan P, Webb A, Zhang X, Pietrzak M, Ghoneim HE, Dubey P, Barrientos RM, Lee RJ, Kokiko-Cochran ON, Amer AO. Badr A, et al. Among authors: yan p. Brain Behav Immun. 2024 May 6:S0889-1591(24)00394-5. doi: 10.1016/j.bbi.2024.05.006. Online ahead of print. Brain Behav Immun. 2024. PMID: 38718909
Cost-effectiveness and cost-utility of a digital technology-driven hierarchical healthcare screening pattern in China.
Wu X, Wu Y, Tu Z, Cao Z, Xu M, Xiang Y, Lin D, Jin L, Zhao L, Zhang Y, Liu Y, Yan P, Hu W, Liu J, Liu L, Wang X, Wang R, Chen J, Xiao W, Shang Y, Xie P, Wang D, Zhang X, Dongye M, Wang C, Ting DSW, Liu Y, Pan R, Lin H. Wu X, et al. Among authors: yan p. Nat Commun. 2024 Apr 30;15(1):3650. doi: 10.1038/s41467-024-47211-w. Nat Commun. 2024. PMID: 38688925 Free PMC article.
3,452 results