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Discovery and characterization of small molecules that target the GTPase Ral.
Yan C, Liu D, Li L, Wempe MF, Guin S, Khanna M, Meier J, Hoffman B, Owens C, Wysoczynski CL, Nitz MD, Knabe WE, Ahmed M, Brautigan DL, Paschal BM, Schwartz MA, Jones DN, Ross D, Meroueh SO, Theodorescu D. Yan C, et al. Nature. 2014 Nov 20;515(7527):443-7. doi: 10.1038/nature13713. Epub 2014 Sep 14. Nature. 2014. PMID: 25219851 Free PMC article.
One step closer to targeting RAS.
Yan C, Theodorescu D. Yan C, et al. Cell Cycle. 2015;14(3):287-8. doi: 10.1080/15384101.2015.1006534. Cell Cycle. 2015. PMID: 25591050 Free PMC article. No abstract available.
Drugging the Ral GTPase.
Yan C, Jones DN, Theodorescu D. Yan C, et al. Small GTPases. 2015;6(3):157-9. doi: 10.1080/21541248.2015.1018403. Small GTPases. 2015. PMID: 26280620 Free PMC article.
Synthesis of novel Ral inhibitors: An in vitro and in vivo study.
Yan C, Theodorescu D, Miller B, Kumar A, Kumar V, Ross D, Wempe MF. Yan C, et al. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5815-5818. doi: 10.1016/j.bmcl.2016.10.021. Epub 2016 Oct 12. Bioorg Med Chem Lett. 2016. PMID: 27825764 Free PMC article.
8,893 results