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Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes.
Nakagawa Y, Satoh A, Yabe S, Furusawa M, Tokushige N, Tezuka H, Mikami M, Iwata W, Shingyouchi A, Matsuzaka T, Kiwata S, Fujimoto Y, Shimizu H, Danno H, Yamamoto T, Ishii K, Karasawa T, Takeuchi Y, Iwasaki H, Shimada M, Kawakami Y, Urayama O, Sone H, Takekoshi K, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Yamada N, Shimano H. Nakagawa Y, et al. Among authors: yamamoto t. Endocrinology. 2014 Dec;155(12):4706-19. doi: 10.1210/en.2014-1113. Epub 2014 Sep 18. Endocrinology. 2014. PMID: 25233440
The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha.
Danno H, Ishii KA, Nakagawa Y, Mikami M, Yamamoto T, Yabe S, Furusawa M, Kumadaki S, Watanabe K, Shimizu H, Matsuzaka T, Kobayashi K, Takahashi A, Yatoh S, Suzuki H, Yamada N, Shimano H. Danno H, et al. Among authors: yamamoto t. Biochem Biophys Res Commun. 2010 Jan 8;391(2):1222-7. doi: 10.1016/j.bbrc.2009.12.046. Epub 2009 Dec 16. Biochem Biophys Res Commun. 2010. PMID: 20006574
SREBPs suppress IRS-2-mediated insulin signalling in the liver.
Ide T, Shimano H, Yahagi N, Matsuzaka T, Nakakuki M, Yamamoto T, Nakagawa Y, Takahashi A, Suzuki H, Sone H, Toyoshima H, Fukamizu A, Yamada N. Ide T, et al. Among authors: yamamoto t. Nat Cell Biol. 2004 Apr;6(4):351-7. doi: 10.1038/ncb1111. Epub 2004 Mar 14. Nat Cell Biol. 2004. PMID: 15048126
Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice.
Kato T, Shimano H, Yamamoto T, Yokoo T, Endo Y, Ishikawa M, Matsuzaka T, Nakagawa Y, Kumadaki S, Yahagi N, Takahashi A, Sone H, Suzuki H, Toyoshima H, Hasty AH, Takahashi S, Gomi H, Izumi T, Yamada N. Kato T, et al. Among authors: yamamoto t. Cell Metab. 2006 Aug;4(2):143-54. doi: 10.1016/j.cmet.2006.06.009. Cell Metab. 2006. PMID: 16890542 Free article.
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
Matsuzaka T, Shimano H, Yahagi N, Kato T, Atsumi A, Yamamoto T, Inoue N, Ishikawa M, Okada S, Ishigaki N, Iwasaki H, Iwasaki Y, Karasawa T, Kumadaki S, Matsui T, Sekiya M, Ohashi K, Hasty AH, Nakagawa Y, Takahashi A, Suzuki H, Yatoh S, Sone H, Toyoshima H, Osuga J, Yamada N. Matsuzaka T, et al. Among authors: yamamoto t. Nat Med. 2007 Oct;13(10):1193-202. doi: 10.1038/nm1662. Epub 2007 Sep 30. Nat Med. 2007. PMID: 17906635
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