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Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein-Protein Interaction Inhibitors.
Otake K, Hara Y, Ubukata M, Inoue M, Nagahashi N, Motoda D, Ogawa N, Hantani Y, Hantani R, Adachi T, Nomura A, Yamaguchi K, Maekawa M, Mamada H, Motomura T, Sato M, Harada K. Otake K, et al. Among authors: yamaguchi k. J Med Chem. 2024 Mar 14;67(5):3741-3763. doi: 10.1021/acs.jmedchem.3c02171. Epub 2024 Feb 26. J Med Chem. 2024. PMID: 38408347
Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1-Nrf2 PPI Inhibitor.
Otake K, Ubukata M, Nagahashi N, Ogawa N, Hantani Y, Hantani R, Adachi T, Nomura A, Yamaguchi K, Maekawa M, Mamada H, Motomura T, Sato M, Harada K. Otake K, et al. Among authors: yamaguchi k. ACS Med Chem Lett. 2023 Apr 7;14(5):658-665. doi: 10.1021/acsmedchemlett.3c00067. eCollection 2023 May 11. ACS Med Chem Lett. 2023. PMID: 37197451 Free PMC article.
Ternary crystal structure of human RORγ ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction.
Noguchi M, Nomura A, Doi S, Yamaguchi K, Hirata K, Shiozaki M, Maeda K, Hirashima S, Kotoku M, Yamaguchi T, Katsuda Y, Crowe P, Tao H, Thacher S, Adachi T. Noguchi M, et al. Among authors: yamaguchi t, yamaguchi k. Sci Rep. 2018 Nov 26;8(1):17374. doi: 10.1038/s41598-018-35783-9. Sci Rep. 2018. PMID: 30478402 Free PMC article.
Ternary complex of human RORγ ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment.
Noguchi M, Nomura A, Murase K, Doi S, Yamaguchi K, Hirata K, Shiozaki M, Hirashima S, Kotoku M, Yamaguchi T, Katsuda Y, Steensma R, Li X, Tao H, Tse B, Fenn M, Babine R, Bradley E, Crowe P, Thacher S, Adachi T, Kamada M. Noguchi M, et al. Among authors: yamaguchi t, yamaguchi k. Genes Cells. 2017 Jun;22(6):535-551. doi: 10.1111/gtc.12494. Epub 2017 May 11. Genes Cells. 2017. PMID: 28493531 Free article.
CD271 mRNA/hnRNPA2B1 complex promotes proliferation and stemness in oral and head and neck squamous cell carcinoma.
Mochizuki M, Shibuya-Takahashi R, Kanno SI, Adachi S, Fujimori H, Nakazato A, Fujii K, Morita S, Saijoh S, Yamazaki T, Imai T, Asada Y, Yamaguchi K, Yasuda J, Shindo N, Sugamura K, Tamai K. Mochizuki M, et al. Among authors: yamaguchi k. Cancer Sci. 2024 May 6. doi: 10.1111/cas.16187. Online ahead of print. Cancer Sci. 2024. PMID: 38710200
7,504 results