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Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis.
Yamada N, Karasawa T, Ito J, Yamamuro D, Morimoto K, Nakamura T, Komada T, Baatarjav C, Saimoto Y, Jinnouchi Y, Watanabe K, Miura K, Yahagi N, Nakagawa K, Matsumura T, Yamada KI, Ishibashi S, Sata N, Conrad M, Takahashi M. Yamada N, et al. Among authors: yahagi n. Nat Commun. 2024 Mar 12;15(1):2195. doi: 10.1038/s41467-024-46386-6. Nat Commun. 2024. PMID: 38472233 Free PMC article.
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
Matsuzaka T, Shimano H, Yahagi N, Kato T, Atsumi A, Yamamoto T, Inoue N, Ishikawa M, Okada S, Ishigaki N, Iwasaki H, Iwasaki Y, Karasawa T, Kumadaki S, Matsui T, Sekiya M, Ohashi K, Hasty AH, Nakagawa Y, Takahashi A, Suzuki H, Yatoh S, Sone H, Toyoshima H, Osuga J, Yamada N. Matsuzaka T, et al. Among authors: yahagi n. Nat Med. 2007 Oct;13(10):1193-202. doi: 10.1038/nm1662. Epub 2007 Sep 30. Nat Med. 2007. PMID: 17906635
Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy.
Osaki Y, Nakagawa Y, Miyahara S, Iwasaki H, Ishii A, Matsuzaka T, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Sone H, Ohashi K, Ishibashi S, Yamada N, Shimano H. Osaki Y, et al. Among authors: yahagi n. Biochem Biophys Res Commun. 2015 Oct 23;466(3):536-40. doi: 10.1016/j.bbrc.2015.09.065. Epub 2015 Sep 14. Biochem Biophys Res Commun. 2015. PMID: 26381177
Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice.
Yahagi N, Shimano H, Hasty AH, Matsuzaka T, Ide T, Yoshikawa T, Amemiya-Kudo M, Tomita S, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Nagai R, Ishibashi S, Yamada N. Yahagi N, et al. J Biol Chem. 2002 May 31;277(22):19353-7. doi: 10.1074/jbc.M201584200. Epub 2002 Mar 28. J Biol Chem. 2002. PMID: 11923308 Free article.
Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling.
Yoshikawa T, Ide T, Shimano H, Yahagi N, Amemiya-Kudo M, Matsuzaka T, Yatoh S, Kitamine T, Okazaki H, Tamura Y, Sekiya M, Takahashi A, Hasty AH, Sato R, Sone H, Osuga J, Ishibashi S, Yamada N. Yoshikawa T, et al. Among authors: yahagi n. Mol Endocrinol. 2003 Jul;17(7):1240-54. doi: 10.1210/me.2002-0190. Epub 2003 May 1. Mol Endocrinol. 2003. PMID: 12730331
p53 Activation in adipocytes of obese mice.
Yahagi N, Shimano H, Matsuzaka T, Najima Y, Sekiya M, Nakagawa Y, Ide T, Tomita S, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Gotoda T, Nagai R, Kimura S, Ishibashi S, Osuga J, Yamada N. Yahagi N, et al. J Biol Chem. 2003 Jul 11;278(28):25395-400. doi: 10.1074/jbc.M302364200. Epub 2003 May 6. J Biol Chem. 2003. PMID: 12734185 Free article.
665 results