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cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis.
Wang L, Jin H, Jochems F, Wang S, Lieftink C, Martinez IM, De Conti G, Edwards F, de Oliveira RL, Schepers A, Zhou Y, Zheng J, Wu W, Zheng X, Yuan S, Ling J, Jastrzebski K, Santos Dias MD, Song JY, Celie PNH, Yagita H, Yao M, Zhou W, Beijersbergen RL, Qin W, Bernards R. Wang L, et al. Among authors: yagita h. Nat Cancer. 2022 Nov;3(11):1284-1299. doi: 10.1038/s43018-022-00462-2. Epub 2022 Nov 22. Nat Cancer. 2022. PMID: 36414711
Oncogenic fusion E2A-HLF sensitizes t(17;19)-positive acute lymphoblastic leukemia to TRAIL-mediated apoptosis by upregulating the expression of death receptors.
Zhang X, Inukai T, Hirose K, Akahane K, Kuroda I, Honna-Oshiro H, Kagami K, Goi K, Nakamura K, Kobayashi M, Endo M, Yagita H, Kurosawa H, Thomas Look A, Honda H, Inaba T, Nakazawa S, Sugita K. Zhang X, et al. Among authors: yagita h. Leukemia. 2012 Dec;26(12):2483-93. doi: 10.1038/leu.2012.139. Epub 2012 May 30. Leukemia. 2012. PMID: 22743623
Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity.
Guicciardi ME, Werneburg NW, Bronk SF, Franke A, Yagita H, Thomas G, Gores GJ. Guicciardi ME, et al. Among authors: yagita h. PLoS One. 2014 Mar 14;9(3):e92124. doi: 10.1371/journal.pone.0092124. eCollection 2014. PLoS One. 2014. PMID: 24633224 Free PMC article.
ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis.
Condamine T, Kumar V, Ramachandran IR, Youn JI, Celis E, Finnberg N, El-Deiry WS, Winograd R, Vonderheide RH, English NR, Knight SC, Yagita H, McCaffrey JC, Antonia S, Hockstein N, Witt R, Masters G, Bauer T, Gabrilovich DI. Condamine T, et al. Among authors: yagita h. J Clin Invest. 2014 Jun;124(6):2626-39. doi: 10.1172/JCI74056. Epub 2014 May 1. J Clin Invest. 2014. PMID: 24789911 Free PMC article.
Systemic FasL and TRAIL neutralisation reduce leishmaniasis induced skin ulceration.
Tasew G, Nylén S, Lieke T, Lemu B, Meless H, Ruffin N, Wolday D, Asseffa A, Yagita H, Britton S, Akuffo H, Chiodi F, Eidsmo L. Tasew G, et al. Among authors: yagita h. PLoS Negl Trop Dis. 2010 Oct 12;4(10):e844. doi: 10.1371/journal.pntd.0000844. PLoS Negl Trop Dis. 2010. PMID: 20967287 Free PMC article.
1,032 results