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Lectin pathway effector enzyme mannan-binding lectin-associated serine protease-2 can activate native complement C3 in absence of C4 and/or C2.
Yaseen S, Demopulos G, Dudler T, Yabuki M, Wood CL, Cummings WJ, Tjoelker LW, Fujita T, Sacks S, Garred P, Andrew P, Sim RB, Lachmann PJ, Wallis R, Lynch N, Schwaeble WJ. Yaseen S, et al. Among authors: yabuki m. FASEB J. 2017 May;31(5):2210-2219. doi: 10.1096/fj.201601306R. Epub 2017 Feb 10. FASEB J. 2017. PMID: 28188176
By using various serum sources with defined complement deficiencies, we demonstrate that, under physiologic conditions LP-specific C4 and/or C2 bypass activation of C3 is mediated by direct cleavage of native C3 by mannan-binding lectin-associated serine protease-2 bound to LP-ac …
By using various serum sources with defined complement deficiencies, we demonstrate that, under physiologic conditions LP-specific C4 and/or …
Inhibition of the Lectin Pathway of Complement Activation Reduces Acute Respiratory Distress Syndrome Severity in a Mouse Model of SARS-CoV-2 Infection.
Ali YM, Carnell GW, Fumagalli S, Mercurio D, Seminara S, Lynch NJ, Khatri P, Arachchilage CH, Mascheroni L, Kaminski C, George CL, Stewart H, Yabuki M, Demopulos G, Heeney JL, Schwaeble W. Ali YM, et al. Among authors: yabuki m. J Infect Dis. 2024 Mar 14;229(3):680-690. doi: 10.1093/infdis/jiad462. J Infect Dis. 2024. PMID: 37878754 Free PMC article.
AID in antibody perfection.
Vallur AC, Yabuki M, Larson ED, Maizels N. Vallur AC, et al. Among authors: yabuki m. Cell Mol Life Sci. 2007 Mar;64(5):555-65. doi: 10.1007/s00018-007-6434-2. Cell Mol Life Sci. 2007. PMID: 17262167
Chromatin structure regulates gene conversion.
Cummings WJ, Yabuki M, Ordinario EC, Bednarski DW, Quay S, Maizels N. Cummings WJ, et al. Among authors: yabuki m. PLoS Biol. 2007 Oct;5(10):e246. doi: 10.1371/journal.pbio.0050246. PLoS Biol. 2007. PMID: 17880262 Free PMC article.
165 results