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SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model.
Qiao J, Li YS, Zeng R, Liu FL, Luo RH, Huang C, Wang YF, Zhang J, Quan B, Shen C, Mao X, Liu X, Sun W, Yang W, Ni X, Wang K, Xu L, Duan ZL, Zou QC, Zhang HL, Qu W, Long YH, Li MH, Yang RC, Liu X, You J, Zhou Y, Yao R, Li WP, Liu JM, Chen P, Liu Y, Lin GF, Yang X, Zou J, Li L, Hu Y, Lu GW, Li WM, Wei YQ, Zheng YT, Lei J, Yang S. Qiao J, et al. Among authors: xu l. Science. 2021 Mar 26;371(6536):1374-1378. doi: 10.1126/science.abf1611. Epub 2021 Feb 18. Science. 2021. PMID: 33602867 Free PMC article.
Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models.
Wang G, Yang ML, Duan ZL, Liu FL, Jin L, Long CB, Zhang M, Tang XP, Xu L, Li YC, Kamau PM, Yang L, Liu HQ, Xu JW, Chen JK, Zheng YT, Peng XZ, Lai R. Wang G, et al. Among authors: xu jw, xu l. Cell Res. 2021 Jan;31(1):17-24. doi: 10.1038/s41422-020-00450-0. Epub 2020 Dec 1. Cell Res. 2021. PMID: 33262453 Free PMC article.
SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target.
Xia B, Shen X, He Y, Pan X, Liu FL, Wang Y, Yang F, Fang S, Wu Y, Duan Z, Zuo X, Xie Z, Jiang X, Xu L, Chi H, Li S, Meng Q, Zhou H, Zhou Y, Cheng X, Xin X, Jin L, Zhang HL, Yu DD, Li MH, Feng XL, Chen J, Jiang H, Xiao G, Zheng YT, Zhang LK, Shen J, Li J, Gao Z. Xia B, et al. Among authors: xu l. Cell Res. 2021 Aug;31(8):847-860. doi: 10.1038/s41422-021-00519-4. Epub 2021 Jun 10. Cell Res. 2021. PMID: 34112954 Free PMC article.
Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation.
Liu FL, Wu K, Sun J, Duan Z, Quan X, Kuang J, Chu S, Pang W, Gao H, Xu L, Li YC, Zhang HL, Wang XH, Luo RH, Feng XL, Schöler HR, Chen X, Pei D, Wu G, Zheng YT, Chen J. Liu FL, et al. Among authors: xu l. Natl Sci Rev. 2020 Nov 24;8(2):nwaa285. doi: 10.1093/nsr/nwaa285. eCollection 2021 Feb. Natl Sci Rev. 2020. PMID: 34676093 Free PMC article. No abstract available.
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