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Danshensu inhibits SARS-CoV-2 by targeting its main protease as a specific covalent inhibitor and discovery of bifunctional compounds eliciting antiviral and anti-inflammatory activity.
Wang R, Chen X, Li H, Chen X, Sun D, Yu D, Lu J, Xie Y, Zhang Q, Xu J, Zhang W, Chen H, Liu S, Chen L. Wang R, et al. Among authors: xu j. Int J Biol Macromol. 2024 Feb;257(Pt 2):128623. doi: 10.1016/j.ijbiomac.2023.128623. Epub 2023 Dec 7. Int J Biol Macromol. 2024. PMID: 38070810
Direct SUMOylation of M1 muscarinic acetylcholine receptor increases its ligand-binding affinity and signal transduction.
Xu J, Tan P, Li H, Cui Y, Qiu Y, Wang H, Zhang X, Li J, Zhu L, Zhou W, Chen H. Xu J, et al. FASEB J. 2019 Mar;33(3):3237-3251. doi: 10.1096/fj.201800936R. Epub 2018 Nov 8. FASEB J. 2019. PMID: 30407877
Our results provide evidence that M1 SUMOylation is an important PTM involved in regulation of the affinity for agonists and for activation of signaling pathways.-Xu, J., Tan, P., Li, H., Cui, Y., Qiu, Y., Wang, H., Zhang, X., Li, J., Zhu, L., Zhou, W., Chen, …
Our results provide evidence that M1 SUMOylation is an important PTM involved in regulation of the affinity for agonists and for activation …
Effects of BIS-MEP on Reversing Amyloid Plaque Deposition and Spatial Learning and Memory Impairments in a Mouse Model of β-Amyloid Peptide- and Ibotenic Acid-Induced Alzheimer's Disease.
Wang Y, Xia J, Shen M, Zhou Y, Wu Z, Shi Y, Xu J, Hou L, Zhang R, Qiu Z, Xie Q, Chen H, Zhang Y, Wang H. Wang Y, et al. Among authors: xu j. Front Aging Neurosci. 2019 Jan 22;11:3. doi: 10.3389/fnagi.2019.00003. eCollection 2019. Front Aging Neurosci. 2019. PMID: 30723404 Free PMC article.
M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 via a signaling pathway linking cAMP-PKA and PI3K-Akt.
Zhao LX, Ge YH, Li JB, Xiong CH, Law PY, Xu JR, Qiu Y, Chen HZ. Zhao LX, et al. FASEB J. 2019 May;33(5):6622-6631. doi: 10.1096/fj.201802351R. Epub 2019 Feb 22. FASEB J. 2019. PMID: 30794430
Taken together, these data demonstrate that M1 receptor activation induces membrane insertion of GluA1 via a signaling linking cAMP-PKA and PI3K-Akt-mTOR pathways but is irrelevant to protein synthesis.-Zhao, L.-X., Ge, Y.-H., Li, J.-B., Xiong, C.-H., Law, P.-Y., Xu …
Taken together, these data demonstrate that M1 receptor activation induces membrane insertion of GluA1 via a signaling linking cAMP-PKA and …
62,117 results
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