Xu J - Search Results

1

Structure-based discovery of nonopioid analgesics acting through the α_2A-adrenergic receptor.

Fink EA, Xu J, Hübner H, Braz JM, Seemann P, Avet C, Craik V, Weikert D, Schmidt MF, Webb CM, Tolmachova NA, Moroz YS, Huang XP, Kalyanaraman C, Gahbauer S, Chen G, Liu Z, Jacobson MP, Irwin JJ, Bouvier M, Du Y, Shoichet BK, Basbaum AI, Gmeiner P. Fink EA, et al. Among authors: xu j. Science. 2022 Sep 30;377(6614):eabn7065. doi: 10.1126/science.abn7065. Epub 2022 Sep 30. Science. 2022. PMID: 36173843 Free PMC article.

2

Structure-based discovery of selective positive allosteric modulators of antagonists for the M₂ muscarinic acetylcholine receptor.

Korczynska M, Clark MJ, Valant C, Xu J, Moo EV, Albold S, Weiss DR, Torosyan H, Huang W, Kruse AC, Lyda BR, May LT, Baltos JA, Sexton PM, Kobilka BK, Christopoulos A, Shoichet BK, Sunahara RK. Korczynska M, et al. Among authors: xu j. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2419-E2428. doi: 10.1073/pnas.1718037115. Epub 2018 Feb 16. Proc Natl Acad Sci U S A. 2018. PMID: 29453275 Free PMC article.

3

Conformational Complexity and Dynamics in a Muscarinic Receptor Revealed by NMR Spectroscopy.

Xu J, Hu Y, Kaindl J, Risel P, Hübner H, Maeda S, Niu X, Li H, Gmeiner P, Jin C, Kobilka BK. Xu J, et al. Mol Cell. 2019 Jul 11;75(1):53-65.e7. doi: 10.1016/j.molcel.2019.04.028. Epub 2019 May 15. Mol Cell. 2019. PMID: 31103421 Free article.

4

Activation of the α_2B adrenoceptor by the sedative sympatholytic dexmedetomidine.

Yuan D, Liu Z, Kaindl J, Maeda S, Zhao J, Sun X, Xu J, Gmeiner P, Wang HW, Kobilka BK. Yuan D, et al. Among authors: xu j. Nat Chem Biol. 2020 May;16(5):507-512. doi: 10.1038/s41589-020-0492-2. Epub 2020 Mar 9. Nat Chem Biol. 2020. PMID: 32152538

5

Structural mechanism underlying primary and secondary coupling between GPCRs and the Gi/o family.

Kim HR, Xu J, Maeda S, Duc NM, Ahn D, Du Y, Chung KY. Kim HR, et al. Among authors: xu j. Nat Commun. 2020 Jun 22;11(1):3160. doi: 10.1038/s41467-020-16975-2. Nat Commun. 2020. PMID: 32572026 Free PMC article.

6

Cryo-EM structure of the AVP-vasopressin receptor 2-G_s signaling complex.

Wang L, Xu J, Cao S, Sun D, Liu H, Lu Q, Liu Z, Du Y, Zhang C. Wang L, et al. Among authors: xu j. Cell Res. 2021 Aug;31(8):932-934. doi: 10.1038/s41422-021-00483-z. Epub 2021 Mar 4. Cell Res. 2021. PMID: 33664408 Free PMC article. No abstract available.

7

Structural insights into ligand recognition, activation, and signaling of the α_2A adrenergic receptor.

Xu J, Cao S, Hübner H, Weikert D, Chen G, Lu Q, Yuan D, Gmeiner P, Liu Z, Du Y. Xu J, et al. Sci Adv. 2022 Mar 4;8(9):eabj5347. doi: 10.1126/sciadv.abj5347. Epub 2022 Mar 4. Sci Adv. 2022. PMID: 35245122 Free PMC article.

8

Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex.

Chen G, Xu J, Inoue A, Schmidt MF, Bai C, Lu Q, Gmeiner P, Liu Z, Du Y. Chen G, et al. Among authors: xu j. Nat Commun. 2022 May 2;13(1):2375. doi: 10.1038/s41467-022-30081-5. Nat Commun. 2022. PMID: 35501348 Free PMC article.

9

Author Correction: Cryo-EM structure of the AVP-vasopressin receptor 2-Gs signaling complex.

Wang L, Xu J, Cao S, Sun D, Liu H, Lu Q, Liu Z, Du Y, Zhang C. Wang L, et al. Among authors: xu j. Cell Res. 2022 Oct;32(10):957. doi: 10.1038/s41422-022-00701-2. Cell Res. 2022. PMID: 36050375 Free PMC article. No abstract available.

10

Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor.

Xu J, Wang Q, Hübner H, Hu Y, Niu X, Wang H, Maeda S, Inoue A, Tao Y, Gmeiner P, Du Y, Jin C, Kobilka BK. Xu J, et al. Nat Commun. 2023 Jan 23;14(1):376. doi: 10.1038/s41467-022-35726-z. Nat Commun. 2023. PMID: 36690613 Free PMC article.

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