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Dual Targeting of CDK4/6 and BCL2 Pathways Augments Tumor Response in Estrogen Receptor-Positive Breast Cancer.
Whittle JR, Vaillant F, Surgenor E, Policheni AN, Giner G, Capaldo BD, Chen HR, Liu HK, Dekkers JF, Sachs N, Clevers H, Fellowes A, Green T, Xu H, Fox SB, Herold MJ, Smyth GK, Gray DHD, Visvader JE, Lindeman GJ. Whittle JR, et al. Among authors: xu h. Clin Cancer Res. 2020 Aug 1;26(15):4120-4134. doi: 10.1158/1078-0432.CCR-19-1872. Epub 2020 Apr 3. Clin Cancer Res. 2020. PMID: 32245900
Enhanced RAD21 cohesin expression confers poor prognosis and resistance to chemotherapy in high grade luminal, basal and HER2 breast cancers.
Xu H, Yan M, Patra J, Natrajan R, Yan Y, Swagemakers S, Tomaszewski JM, Verschoor S, Millar EK, van der Spek P, Reis-Filho JS, Ramsay RG, O'Toole SA, McNeil CM, Sutherland RL, McKay MJ, Fox SB. Xu H, et al. Breast Cancer Res. 2011 Jan 21;13(1):R9. doi: 10.1186/bcr2814. Breast Cancer Res. 2011. PMID: 21255398 Free PMC article.
Profound MEK inhibitor response in a cutaneous melanoma harboring a GOLGA4-RAF1 fusion.
McEvoy CR, Xu H, Smith K, Etemadmoghadam D, San Leong H, Choong DY, Byrne DJ, Iravani A, Beck S, Mileshkin L, Tothill RW, Bowtell DD, Bates BM, Nastevski V, Browning J, Bell AH, Khoo C, Desai J, Fellowes AP, Fox SB, Prall OW. McEvoy CR, et al. Among authors: xu h. J Clin Invest. 2019 May 1;129(5):1940-1945. doi: 10.1172/JCI123089. Epub 2019 Mar 5. J Clin Invest. 2019. PMID: 30835257 Free PMC article.
RAF1 rearrangements are common in pancreatic acinar cell carcinomas.
Prall OWJ, Nastevski V, Xu H, McEvoy CRE, Vissers JHA, Byrne DJ, Takano E, Yerneni S, Ellis S, Green T, Mitchell CA, Murray WK, Scott CL, Grimmond SM, Hofmann O, Papenfuss A, Kee D, Fellowes A, Brown IS, Miller G, Kumarasinghe MP, Perren A, Nahm CB, Mittal A, Samra J, Ahadi M, Fox SB, Chou A, Gill AJ. Prall OWJ, et al. Among authors: xu h. Mod Pathol. 2020 Sep;33(9):1811-1821. doi: 10.1038/s41379-020-0545-9. Mod Pathol. 2020. PMID: 32358589 Free article.
A MXI1-NUTM1 fusion protein with MYC-like activity suggests a novel oncogenic mechanism in a subset of NUTM1-rearranged tumors.
McEvoy CR, Holliday H, Thio N, Mitchell C, Choong DY, Yellapu B, Leong HS, Xu H, Lade S, Browning J, Takano EA, Byrne DJ, Gill AJ, Duong CP, Li J, Fellowes AP, Fox SB, Swarbrick A, Prall OWJ. McEvoy CR, et al. Among authors: xu h. Lab Invest. 2021 Jan;101(1):26-37. doi: 10.1038/s41374-020-00484-3. Epub 2020 Sep 1. Lab Invest. 2021. PMID: 32873880 Free article.
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