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EML4-ALK fusions drive lung adeno-to-squamous transition through JAK-STAT activation.
Qin Z, Yue M, Tang S, Wu F, Sun H, Li Y, Zhang Y, Izumi H, Huang H, Wang W, Xue Y, Tong X, Mori S, Taki T, Goto K, Jin Y, Li F, Li FM, Gao Y, Fang Z, Fang Y, Hu L, Yan X, Xu G, Chen H, Kobayashi SS, Ventura A, Wong KK, Zhu X, Chen L, Ren S, Chen LN, Ji H. Qin Z, et al. Among authors: xu g. J Exp Med. 2024 Mar 4;221(3):e20232028. doi: 10.1084/jem.20232028. Epub 2024 Jan 29. J Exp Med. 2024. PMID: 38284990
Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs.
Ma S, Wan X, Deng Z, Shi L, Hao C, Zhou Z, Zhou C, Fang Y, Liu J, Yang J, Chen X, Li T, Zang A, Yin S, Li B, Plumas J, Chaperot L, Zhang X, Xu G, Jiang L, Shen N, Xiong S, Gao X, Zhang Y, Xiao H. Ma S, et al. Among authors: xu g. J Exp Med. 2017 May 1;214(5):1471-1491. doi: 10.1084/jem.20161149. Epub 2017 Apr 17. J Exp Med. 2017. PMID: 28416650 Free PMC article.
A vitamin-C-derived DNA modification catalysed by an algal TET homologue.
Xue JH, Chen GD, Hao F, Chen H, Fang Z, Chen FF, Pang B, Yang QL, Wei X, Fan QQ, Xin C, Zhao J, Deng X, Wang BA, Zhang XJ, Chu Y, Tang H, Yin H, Ma W, Chen L, Ding J, Weinhold E, Kohli RM, Liu W, Zhu ZJ, Huang K, Tang H, Xu GL. Xue JH, et al. Nature. 2019 May;569(7757):581-585. doi: 10.1038/s41586-019-1160-0. Epub 2019 May 1. Nature. 2019. PMID: 31043749 Free PMC article.
DCK confers sensitivity of DCTD-positive cancer cells to oxidized methylcytidines.
Zhao YH, Jiang W, Gao H, Pang GZ, Wu YS, Wang YX, Sheng MY, Xie JY, Wu WL, Ji ZJ, Du YR, Zhang L, Wang XQ, Walsh CP, Jiang H, Xu GL, Zhou D. Zhao YH, et al. Protein Cell. 2023 Jun 28;14(7):532-537. doi: 10.1093/procel/pwac028. Protein Cell. 2023. PMID: 37378658 Free PMC article. No abstract available.
STING activation in TET2-mutated hematopoietic stem/progenitor cells contributes to the increased self-renewal and neoplastic transformation.
Xie J, Sheng M, Rong S, Zhou D, Wang C, Wu W, Huang J, Sun Y, Wang Y, Chen P, Wu Y, Wang Y, Wang L, Zhou BO, Huang X, Walsh CP, Bohlander SK, Huang J, Wang X, Xu GL, Gao H, Shi Y. Xie J, et al. Leukemia. 2023 Dec;37(12):2457-2467. doi: 10.1038/s41375-023-02055-z. Epub 2023 Oct 10. Leukemia. 2023. PMID: 37816954 Free PMC article.
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