Hypoxic-stabilized EPAS1 proteins transactivate DNMT1 and cause promoter hypermethylation and transcription inhibition of EPAS1 in non-small cell lung cancer.
Xu XH, Bao Y, Wang X, Yan F, Guo S, Ma Y, Xu D, Jin L, Xu J, Wang J.
Xu XH, et al. Among authors: xu d, xu j.
FASEB J. 2018 Jun 19:fj201700715. doi: 10.1096/fj.201700715. Online ahead of print.
FASEB J. 2018.
PMID: 29920222
That is, hypoxic-stabilized EPAS1 proteins transactivated DNMT1, which further promoted the hypermethylation of EPAS1 promoter and decreased EPAS1 mRNA expression levels in NSCLC.-Xu, X.-H., Bao, Y., Wang, X., Yan, F., Guo, S., Ma, Y., Xu, D., Jin, L., Xu …
That is, hypoxic-stabilized EPAS1 proteins transactivated DNMT1, which further promoted the hypermethylation of EPAS1 promoter and decreased …