Xu A - Search Results

1

Novel T-cell-based vaccines via arming polyclonal CD4⁺ T cells with antigen-specific exosomes.

Xu A, Freywald A, Xiang J. Xu A, et al. Immunotherapy. 2016 Nov;8(11):1265-1269. doi: 10.2217/imt-2016-0094. Immunotherapy. 2016. PMID: 27993084 No abstract available.

2

Novel exosome-targeted T-cell-based vaccine counteracts T-cell anergy and converts CTL exhaustion in chronic infection via CD40L signaling through the mTORC1 pathway.

Wang R, Xu A, Zhang X, Wu J, Freywald A, Xu J, Xiang J. Wang R, et al. Among authors: xu a, xu j. Cell Mol Immunol. 2017 Jun;14(6):529-545. doi: 10.1038/cmi.2016.23. Epub 2016 Jun 6. Cell Mol Immunol. 2017. PMID: 27264687 Free PMC article.

3

Enhanced suppression of polyclonal CD8⁺25⁺ regulatory T cells via exosomal arming of antigen-specific peptide/MHC complexes.

Mu C, Zhang X, Wang L, Xu A, Ahmed KA, Pang X, Chibbar R, Freywald A, Huang J, Zhu Y, Xiang J. Mu C, et al. Among authors: xu a. J Leukoc Biol. 2017 May;101(5):1221-1231. doi: 10.1189/jlb.3A0716-295RR. Epub 2017 Jan 17. J Leukoc Biol. 2017. PMID: 28096300

4

CD40 agonist converting CTL exhaustion via the activation of the mTORC1 pathway enhances PD-1 antagonist action in rescuing exhausted CTLs in chronic infection.

Xu A, Wang R, Freywald A, Stewart K, Tikoo S, Xu J, Zheng C, Xiang J. Xu A, et al. Among authors: xu j. Biochem Biophys Res Commun. 2017 Mar 11;484(3):662-667. doi: 10.1016/j.bbrc.2017.01.172. Epub 2017 Jan 31. Biochem Biophys Res Commun. 2017. PMID: 28153727

5

CD8⁺ memory T-cell inflation renders compromised CD4⁺ T-cell-dependent CD8⁺ T-cell immunity via naïve T-cell anergy.

Xu A, Freywald A, Xie Y, Li Z, Xiang J. Xu A, et al. Immunotargets Ther. 2017 Jun 15;6:39-49. doi: 10.2147/ITT.S131662. eCollection 2017. Immunotargets Ther. 2017. PMID: 28670575 Free PMC article.

6

Heterologous human/rat HER2-specific exosome-targeted T cell vaccine stimulates potent humoral and CTL responses leading to enhanced circumvention of HER2 tolerance in double transgenic HLA-A2/HER2 mice.

Xie Y, Wu J, Xu A, Ahmeqd S, Sami A, Chibbar R, Freywald A, Zheng C, Xiang J. Xie Y, et al. Among authors: xu a. Vaccine. 2018 Mar 7;36(11):1414-1422. doi: 10.1016/j.vaccine.2018.01.078. Epub 2018 Feb 5. Vaccine. 2018. PMID: 29415817

7

Simulated microgravity inhibits cell focal adhesions leading to reduced melanoma cell proliferation and metastasis via FAK/RhoA-regulated mTORC1 and AMPK pathways.

Tan X, Xu A, Zhao T, Zhao Q, Zhang J, Fan C, Deng Y, Freywald A, Genth H, Xiang J. Tan X, et al. Among authors: xu a. Sci Rep. 2018 Feb 28;8(1):3769. doi: 10.1038/s41598-018-20459-1. Sci Rep. 2018. PMID: 29491429 Free PMC article.

8

TLR9 agonist enhances radiofrequency ablation-induced CTL responses, leading to the potent inhibition of primary tumor growth and lung metastasis.

Xu A, Zhang L, Yuan J, Babikr F, Freywald A, Chibbar R, Moser M, Zhang W, Zhang B, Fu Z, Xiang J. Xu A, et al. Cell Mol Immunol. 2019 Oct;16(10):820-832. doi: 10.1038/s41423-018-0184-y. Epub 2018 Nov 22. Cell Mol Immunol. 2019. PMID: 30467420 Free PMC article.

9

Distinct roles but cooperative effect of TLR3/9 agonists and PD-1 blockade in converting the immunotolerant microenvironment of irreversible electroporation-ablated tumors.

Babikr F, Wan J, Xu A, Wu Z, Ahmed S, Freywald A, Chibbar R, Wu Y, Moser M, Groot G, Zhang W, Zhang B, Xiang J. Babikr F, et al. Among authors: xu a. Cell Mol Immunol. 2021 Dec;18(12):2632-2647. doi: 10.1038/s41423-021-00796-4. Epub 2021 Nov 15. Cell Mol Immunol. 2021. PMID: 34782757 Free PMC article.

10

Potent immunotherapy against well-established thymoma using adoptively transferred transgene IL-6-engineered dendritic cell-stimulated CD8+ T-cells with prolonged survival and enhanced cytotoxicity.

Kalyanasundaram Bhanumathy K, Zhang B, Xie Y, Xu A, Tan X, Xiang J. Kalyanasundaram Bhanumathy K, et al. Among authors: xu a. J Gene Med. 2015 Aug-Sep;17(8-9):153-60. doi: 10.1002/jgm.2836. J Gene Med. 2015. PMID: 26212685

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