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Phase separation underlies signaling activation of oncogenic NTRK fusions.
Zhu T, Xie J, He H, Li H, Tang X, Wang S, Li Z, Tian Y, Li L, Zhu J, Zhu G. Zhu T, et al. Among authors: xie j. Proc Natl Acad Sci U S A. 2023 Oct 17;120(42):e2219589120. doi: 10.1073/pnas.2219589120. Epub 2023 Oct 9. Proc Natl Acad Sci U S A. 2023. PMID: 37812694 Free PMC article.
Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation.
Zhu G, Xie J, Kong W, Xie J, Li Y, Du L, Zheng Q, Sun L, Guan M, Li H, Zhu T, He H, Liu Z, Xia X, Kan C, Tao Y, Shen HC, Li D, Wang S, Yu Y, Yu ZH, Zhang ZY, Liu C, Zhu J. Zhu G, et al. Among authors: xie j. Cell. 2020 Oct 15;183(2):490-502.e18. doi: 10.1016/j.cell.2020.09.002. Epub 2020 Sep 30. Cell. 2020. PMID: 33002410 Free PMC article.
A novel partially open state of SHP2 points to a "multiple gear" regulation mechanism.
Tao Y, Xie J, Zhong Q, Wang Y, Zhang S, Luo F, Wen F, Xie J, Zhao J, Sun X, Long H, Ma J, Zhang Q, Long J, Fang X, Lu Y, Li D, Li M, Zhu J, Sun B, Li G, Diao J, Liu C. Tao Y, et al. Among authors: xie j. J Biol Chem. 2021 Jan-Jun;296:100538. doi: 10.1016/j.jbc.2021.100538. Epub 2021 Mar 12. J Biol Chem. 2021. PMID: 33722610 Free PMC article.
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