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LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration.
Deng M, Gui X, Kim J, Xie L, Chen W, Li Z, He L, Chen Y, Chen H, Luo W, Lu Z, Xie J, Churchill H, Xu Y, Zhou Z, Wu G, Yu C, John S, Hirayasu K, Nguyen N, Liu X, Huang F, Li L, Deng H, Tang H, Sadek AH, Zhang L, Huang T, Zou Y, Chen B, Zhu H, Arase H, Xia N, Jiang Y, Collins R, You MJ, Homsi J, Unni N, Lewis C, Chen GQ, Fu YX, Liao XC, An Z, Zheng J, Zhang N, Zhang CC. Deng M, et al. Among authors: xie j, xie l. Nature. 2018 Oct;562(7728):605-609. doi: 10.1038/s41586-018-0615-z. Epub 2018 Oct 17. Nature. 2018. PMID: 30333625 Free PMC article.
Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development.
Gui X, Deng M, Song H, Chen Y, Xie J, Li Z, He L, Huang F, Xu Y, Anami Y, Yu H, Yu C, Li L, Yuan Z, Xu X, Wang Q, Chai Y, Huang T, Shi Y, Tsuchikama K, Liao XC, Xia N, Gao GF, Zhang N, Zhang CC, An Z. Gui X, et al. Among authors: xie j. Cancer Immunol Res. 2019 Aug;7(8):1244-1257. doi: 10.1158/2326-6066.CIR-19-0036. Epub 2019 Jun 18. Cancer Immunol Res. 2019. PMID: 31213474 Free PMC article.
ACER3 supports development of acute myeloid leukemia.
Chen C, Yin Y, Li C, Chen J, Xie J, Lu Z, Li M, Wang Y, Zhang CC. Chen C, et al. Among authors: xie j. Biochem Biophys Res Commun. 2016 Sep 9;478(1):33-38. doi: 10.1016/j.bbrc.2016.07.099. Epub 2016 Jul 25. Biochem Biophys Res Commun. 2016. PMID: 27470583
Blocking LAIR1 signaling in immune cells inhibits tumor development.
Xie J, Gui X, Deng M, Chen H, Chen Y, Liu X, Ku Z, Tan L, Huang R, He Y, Zhang B, Lewis C, Chen K, Xu L, Xu J, Huang T, Liao XC, Zhang N, An Z, Zhang CC. Xie J, et al. Front Immunol. 2022 Sep 21;13:996026. doi: 10.3389/fimmu.2022.996026. eCollection 2022. Front Immunol. 2022. PMID: 36211388 Free PMC article.
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