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A novel human disease with abnormal prion protein sensitive to protease.
Gambetti P, Dong Z, Yuan J, Xiao X, Zheng M, Alshekhlee A, Castellani R, Cohen M, Barria MA, Gonzalez-Romero D, Belay ED, Schonberger LB, Marder K, Harris C, Burke JR, Montine T, Wisniewski T, Dickson DW, Soto C, Hulette CM, Mastrianni JA, Kong Q, Zou WQ. Gambetti P, et al. Among authors: xiao x. Ann Neurol. 2008 Jun;63(6):697-708. doi: 10.1002/ana.21420. Ann Neurol. 2008. PMID: 18571782 Free PMC article.
Variably protease-sensitive prionopathy: a new sporadic disease of the prion protein.
Zou WQ, Puoti G, Xiao X, Yuan J, Qing L, Cali I, Shimoji M, Langeveld JP, Castellani R, Notari S, Crain B, Schmidt RE, Geschwind M, Dearmond SJ, Cairns NJ, Dickson D, Honig L, Torres JM, Mastrianni J, Capellari S, Giaccone G, Belay ED, Schonberger LB, Cohen M, Perry G, Kong Q, Parchi P, Tagliavini F, Gambetti P. Zou WQ, et al. Among authors: xiao x. Ann Neurol. 2010 Aug;68(2):162-72. doi: 10.1002/ana.22094. Ann Neurol. 2010. PMID: 20695009 Free PMC article.
Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain.
Zou WQ, Xiao X, Yuan J, Puoti G, Fujioka H, Wang X, Richardson S, Zhou X, Zou R, Li S, Zhu X, McGeer PL, McGeehan J, Kneale G, Rincon-Limas DE, Fernandez-Funez P, Lee HG, Smith MA, Petersen RB, Guo JP. Zou WQ, et al. Among authors: xiao x. J Biol Chem. 2011 Apr 29;286(17):15095-105. doi: 10.1074/jbc.M110.199356. Epub 2011 Mar 10. J Biol Chem. 2011. PMID: 21393248 Free PMC article.
Recombinant human prion protein inhibits prion propagation in vitro.
Yuan J, Zhan YA, Abskharon R, Xiao X, Martinez MC, Zhou X, Kneale G, Mikol J, Lehmann S, Surewicz WK, Castilla J, Steyaert J, Zhang S, Kong Q, Petersen RB, Wohlkonig A, Zou WQ. Yuan J, et al. Among authors: xiao x. Sci Rep. 2013 Oct 9;3:2911. doi: 10.1038/srep02911. Sci Rep. 2013. PMID: 24105336 Free PMC article.
Synthetic Aβ peptides acquire prion-like properties in the brain.
Xiao X, Cali I, Yuan J, Cracco L, Curtiss P, Zeng L, Abouelsaad M, Gazgalis D, Wang GX, Kong Q, Fujioka H, Puoti G, Zou WQ. Xiao X, et al. Oncotarget. 2015 Jan 20;6(2):642-50. doi: 10.18632/oncotarget.2819. Oncotarget. 2015. PMID: 25460507 Free PMC article.
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