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Histone demethylase JMJD3 regulates fibroblast-like synoviocyte-mediated proliferation and joint destruction in rheumatoid arthritis.
Jia W, Wu W, Yang D, Xiao C, Su Z, Huang Z, Li Z, Qin M, Huang M, Liu S, Long F, Mao J, Liu X, Zhu YZ. Jia W, et al. Among authors: xiao c. FASEB J. 2018 Jul;32(7):4031-4042. doi: 10.1096/fj.201701483R. Epub 2018 Feb 26. FASEB J. 2018. PMID: 29481307
Epigenetic changes have been implicated in the development of some autoimmune disorders, resulting in an alteration of gene transcription. Here, we investigated how Jumonji C family of histone demethylases (JMJD3) regulated the proliferation and activation of fibroblast-li …
Epigenetic changes have been implicated in the development of some autoimmune disorders, resulting in an alteration of gene transcription. H …
Fra-1 plays a critical role in angiotensin II-induced vascular senescence.
Yang D, Xiao C, Long F, Wu W, Huang M, Qu L, Liu X, Zhu Y. Yang D, et al. Among authors: xiao c. FASEB J. 2019 Jun;33(6):7603-7614. doi: 10.1096/fj.201801671RRRR. Epub 2019 Mar 20. FASEB J. 2019. PMID: 30892941
Mechanistic studies reveal that Fra-1 preferentially associates with c-Jun and binds to the cyclin-dependent kinase inhibitor 1a (p21) and cyclin-dependent kinase inhibitor 2a (p16) promoter region, leading to elevated gene expression, which causes senescence-related pheno …
Mechanistic studies reveal that Fra-1 preferentially associates with c-Jun and binds to the cyclin-dependent kinase inhibitor 1a (p21 …
5,321 results