Xiang W - Search Results

1

A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathies.

Hartlage-Rübsamen M, Bluhm A, Moceri S, Machner L, Köppen J, Schenk M, Hilbrich I, Holzer M, Weidenfeller M, Richter F, Coras R, Serrano GE, Beach TG, Schilling S, von Hörsten S, Xiang W, Schulze A, Roßner S. Hartlage-Rübsamen M, et al. Among authors: xiang w. Acta Neuropathol. 2021 Sep;142(3):399-421. doi: 10.1007/s00401-021-02349-5. Epub 2021 Jul 26. Acta Neuropathol. 2021. PMID: 34309760 Free PMC article.

2

Oxidative stress-induced posttranslational modifications of alpha-synuclein: specific modification of alpha-synuclein by 4-hydroxy-2-nonenal increases dopaminergic toxicity.

Xiang W, Schlachetzki JC, Helling S, Bussmann JC, Berlinghof M, Schäffer TE, Marcus K, Winkler J, Klucken J, Becker CM. Xiang W, et al. Mol Cell Neurosci. 2013 May;54:71-83. doi: 10.1016/j.mcn.2013.01.004. Epub 2013 Jan 28. Mol Cell Neurosci. 2013. PMID: 23369945

3

Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment.

Poehler AM, Xiang W, Spitzer P, May VE, Meixner H, Rockenstein E, Chutna O, Outeiro TF, Winkler J, Masliah E, Klucken J. Poehler AM, et al. Among authors: xiang w. Autophagy. 2014;10(12):2171-92. doi: 10.4161/auto.36436. Autophagy. 2014. PMID: 25484190 Free PMC article.

4

Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity.

Xiang W, Menges S, Schlachetzki JC, Meixner H, Hoffmann AC, Schlötzer-Schrehardt U, Becker CM, Winkler J, Klucken J. Xiang W, et al. Mol Neurodegener. 2015 Mar 11;10:8. doi: 10.1186/s13024-015-0004-0. Mol Neurodegener. 2015. PMID: 25886189 Free PMC article.

5

Treadmill exercise intervention improves gait and postural control in alpha-synuclein mouse models without inducing cerebral autophagy.

Minakaki G, Canneva F, Chevessier F, Bode F, Menges S, Timotius IK, Kalinichenko LS, Meixner H, Müller CP, Eskofier BM, Casadei N, Riess O, Schröder R, Winkler J, Xiang W, von Hörsten S, Klucken J. Minakaki G, et al. Among authors: xiang w. Behav Brain Res. 2019 May 2;363:199-215. doi: 10.1016/j.bbr.2018.11.035. Epub 2018 Dec 30. Behav Brain Res. 2019. PMID: 30599154

6

Demonstration of brain region-specific neuronal vulnerability in human iPSC-based model of familial Parkinson's disease.

Brazdis RM, Alecu JE, Marsch D, Dahms A, Simmnacher K, Lörentz S, Brendler A, Schneider Y, Marxreiter F, Roybon L, Winner B, Xiang W, Prots I. Brazdis RM, et al. Among authors: xiang w. Hum Mol Genet. 2020 May 8;29(7):1180-1191. doi: 10.1093/hmg/ddaa039. Hum Mol Genet. 2020. PMID: 32160287 Free PMC article.

7

Compensatory neuritogenesis of serotonergic afferents within the striatum of a transgenic rat model of Parkinson's disease.

Stemick J, Gauer C, Wihan J, Moceri S, Xiang W, von Hörsten S, Kohl Z, Winkler J. Stemick J, et al. Among authors: xiang w. Brain Res. 2020 Dec 1;1748:147119. doi: 10.1016/j.brainres.2020.147119. Epub 2020 Sep 10. Brain Res. 2020. PMID: 32919983 Free article.

8

Toxic Metamorphosis-How Changes from Lysosomal to Cytosolic pH Modify the Alpha-Synuclein Aggregation Pattern.

Eymsh B, Drobny A, Heyn TR, Xiang W, Lucius R, Schwarz K, Keppler JK, Zunke F, Arnold P. Eymsh B, et al. Among authors: xiang w. Biomacromolecules. 2020 Dec 14;21(12):4673-4684. doi: 10.1021/acs.biomac.0c00629. Epub 2020 Oct 13. Biomacromolecules. 2020. PMID: 32986422

9

Interaction of Alpha Synuclein and Microtubule Organization Is Linked to Impaired Neuritic Integrity in Parkinson's Patient-Derived Neuronal Cells.

Seebauer L, Schneider Y, Drobny A, Plötz S, Koudelka T, Tholey A, Prots I, Winner B, Zunke F, Winkler J, Xiang W. Seebauer L, et al. Among authors: xiang w. Int J Mol Sci. 2022 Feb 5;23(3):1812. doi: 10.3390/ijms23031812. Int J Mol Sci. 2022. PMID: 35163733 Free PMC article.

10

Detection of neuron-derived pathological α-synuclein in blood.

Kluge A, Bunk J, Schaeffer E, Drobny A, Xiang W, Knacke H, Bub S, Lückstädt W, Arnold P, Lucius R, Berg D, Zunke F. Kluge A, et al. Among authors: xiang w. Brain. 2022 Sep 14;145(9):3058-3071. doi: 10.1093/brain/awac115. Brain. 2022. PMID: 35722765

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