Xia CQ - Search Results

1

Preclinical Antitumor Activity and Biodistribution of a Novel Anti-GCC Antibody-Drug Conjugate in Patient-derived Xenografts.

Abu-Yousif AO, Cvet D, Gallery M, Bannerman BM, Ganno ML, Smith MD, Lai KC, Keating TA, Stringer B, Kamali A, Eng K, Koseoglu S, Zhu A, Xia CQ, Landen MS, Borland M, Robertson R, Bolleddula J, Qian MG, Fretland J, Veiby OP. Abu-Yousif AO, et al. Among authors: xia cq. Mol Cancer Ther. 2020 Oct;19(10):2079-2088. doi: 10.1158/1535-7163.MCT-19-1102. Epub 2020 Aug 11. Mol Cancer Ther. 2020. PMID: 32788205

2

The relationship among tumor architecture, pharmacokinetics, pharmacodynamics, and efficacy of bortezomib in mouse xenograft models.

Williamson MJ, Silva MD, Terkelsen J, Robertson R, Yu L, Xia C, Hatsis P, Bannerman B, Babcock T, Cao Y, Kupperman E. Williamson MJ, et al. Mol Cancer Ther. 2009 Dec;8(12):3234-43. doi: 10.1158/1535-7163.MCT-09-0239. Mol Cancer Ther. 2009. PMID: 19934276

3

KRAS Genotype Correlates with Proteasome Inhibitor Ixazomib Activity in Preclinical In Vivo Models of Colon and Non-Small Cell Lung Cancer: Potential Role of Tumor Metabolism.

Chattopadhyay N, Berger AJ, Koenig E, Bannerman B, Garnsey J, Bernard H, Hales P, Maldonado Lopez A, Yang Y, Donelan J, Jordan K, Tirrell S, Stringer B, Xia C, Hather G, Galvin K, Manfredi M, Rhodes N, Amidon B. Chattopadhyay N, et al. PLoS One. 2015 Dec 28;10(12):e0144825. doi: 10.1371/journal.pone.0144825. eCollection 2015. PLoS One. 2015. PMID: 26709701 Free PMC article.

4

A Translational Physiologically Based Pharmacokinetics/Pharmacodynamics Framework of Target-Mediated Disposition, Target Inhibition and Drug-Drug Interactions of Bortezomib.

Iwasaki S, Zhu A, Hanley M, Venkatakrishnan K, Xia C. Iwasaki S, et al. AAPS J. 2020 Apr 14;22(3):66. doi: 10.1208/s12248-020-00448-x. AAPS J. 2020. PMID: 32291610

5

Utilizing In Vitro Dissolution-Permeation Chamber for the Quantitative Prediction of pH-Dependent Drug-Drug Interactions with Acid-Reducing Agents: a Comparison with Physiologically Based Pharmacokinetic Modeling.

Zhu AZ, Ho MD, Gemski CK, Chuang BC, Liao M, Xia CQ. Zhu AZ, et al. Among authors: xia cq. AAPS J. 2016 Nov;18(6):1512-1523. doi: 10.1208/s12248-016-9972-4. Epub 2016 Sep 6. AAPS J. 2016. PMID: 27600136

6

Comparison of uptake transporter functions in hepatocytes in different species to determine the optimal model for evaluating drug transporter activities in humans.

Liao M, Zhu Q, Zhu A, Gemski C, Ma B, Guan E, Li AP, Xiao G, Xia CQ. Liao M, et al. Among authors: xia cq. Xenobiotica. 2019 Jul;49(7):852-862. doi: 10.1080/00498254.2018.1512017. Epub 2018 Sep 21. Xenobiotica. 2019. PMID: 30132394

7

Preclinical drug metabolism and pharmacokinetics, and prediction of human pharmacokinetics and efficacious dose of the investigational Aurora A kinase inhibitor alisertib (MLN8237).

Yang JJ, Li Y, Chakravarty A, Lu C, Xia CQ, Chen S, Pusalkar S, Zhang M, Ecsedy J, Manfredi MG, Wu JT, Shyu WC, Balani SK. Yang JJ, et al. Among authors: xia cq. Drug Metab Lett. 2014 Jul;7(2):96-104. doi: 10.2174/1872312807666131229122359. Drug Metab Lett. 2014. PMID: 24484538

8

A Reduction in B, T, and Natural Killer Cells Expressing CD38 by TAK-079 Inhibits the Induction and Progression of Collagen-Induced Arthritis in Cynomolgus Monkeys.

Korver W, Carsillo M, Yuan J, Idamakanti N, Wagoner M, Shi P, Xia CQ, Smithson G, McLean L, Zalevsky J, Fedyk ER. Korver W, et al. Among authors: xia cq. J Pharmacol Exp Ther. 2019 Aug;370(2):182-196. doi: 10.1124/jpet.119.256602. Epub 2019 May 13. J Pharmacol Exp Ther. 2019. PMID: 31085699

9

Drug efflux transporters and multidrug resistance in acute leukemia: therapeutic impact and novel approaches to mediation.

Xia CQ, Smith PG. Xia CQ, et al. Mol Pharmacol. 2012 Dec;82(6):1008-21. doi: 10.1124/mol.112.079129. Epub 2012 Jul 23. Mol Pharmacol. 2012. PMID: 22826468 Review.

10

Predicting Approximate Clinically Effective Doses in Oncology Using Preclinical Efficacy and Body Surface Area Conversion: A Retrospective Analysis.

Griffin RJ, Avery E, Xia CQ. Griffin RJ, et al. Among authors: xia cq. Front Pharmacol. 2022 Apr 26;13:830972. doi: 10.3389/fphar.2022.830972. eCollection 2022. Front Pharmacol. 2022. PMID: 35559235 Free PMC article.

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