Xia A - Search Results

1

A new generation M^pro inhibitor with potent activity against SARS-CoV-2 Omicron variants.

Huang C, Shuai H, Qiao J, Hou Y, Zeng R, Xia A, Xie L, Fang Z, Li Y, Yoon C, Huang Q, Hu B, You J, Quan B, Zhao X, Guo N, Zhang S, Ma R, Zhang J, Wang Y, Yang R, Zhang S, Nan J, Xu H, Wang F, Lei J, Chu H, Yang S. Huang C, et al. Among authors: xia a. Signal Transduct Target Ther. 2023 Mar 16;8(1):128. doi: 10.1038/s41392-023-01392-w. Signal Transduct Target Ther. 2023. PMID: 36928316 Free PMC article.

2

Metal-Free Aerobic Oxidative Selective C-C Bond Cleavage in Heteroaryl-Containing Primary and Secondary Alcohols.

Xia A, Qi X, Mao X, Wu X, Yang X, Zhang R, Xiang Z, Lian Z, Chen Y, Yang S. Xia A, et al. Org Lett. 2019 May 3;21(9):3028-3033. doi: 10.1021/acs.orglett.9b00563. Epub 2019 Apr 17. Org Lett. 2019. PMID: 30995066

3

Discovery of 1,8-disubstituted-[1,2,3]triazolo[4,5-c]quinoline derivatives as a new class of Hippo signaling pathway inhibitors.

Qiao J, Lin G, Xia A, Xiang Z, Chen P, Zhang G, Li L, Yang S. Qiao J, et al. Among authors: xia a. Bioorg Med Chem Lett. 2019 Sep 15;29(18):2595-2603. doi: 10.1016/j.bmcl.2019.08.001. Epub 2019 Aug 2. Bioorg Med Chem Lett. 2019. PMID: 31400941

4

Structure-Guided Discovery of a Potent and Selective Cell-Active Inhibitor of SETDB1 Tudor Domain.

Guo Y, Mao X, Xiong L, Xia A, You J, Lin G, Wu C, Huang L, Wang Y, Yang S. Guo Y, et al. Among authors: xia a. Angew Chem Int Ed Engl. 2021 Apr 12;60(16):8760-8765. doi: 10.1002/anie.202017200. Epub 2021 Mar 8. Angew Chem Int Ed Engl. 2021. PMID: 33511756

5

Discovery of 3,6-disubstutited-imidazo[1,2-a]pyridine derivatives as a new class of CLK1 inhibitors.

Zhang Y, Xia A, Zhang S, Lin G, Liu J, Chen P, Mu B, Jiao Y, Xu W, Chen M, Li L. Zhang Y, et al. Among authors: xia a. Bioorg Med Chem Lett. 2021 Jun 1;41:127881. doi: 10.1016/j.bmcl.2021.127881. Epub 2021 Mar 2. Bioorg Med Chem Lett. 2021. PMID: 33662541

6

Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis.

Jiao Y, Nan J, Mu B, Zhang Y, Zhou N, Yang S, Zhang S, Lin W, Wang F, Xia A, Cao Z, Chen P, Pan Z, Lin G, Pan S, Bin H, Li L, Yang S. Jiao Y, et al. Among authors: xia a. Eur J Med Chem. 2022 Mar 15;232:114194. doi: 10.1016/j.ejmech.2022.114194. Epub 2022 Feb 11. Eur J Med Chem. 2022. PMID: 35183871

7

Discovery of 6,7-dihydro-5H-pyrrolo[3,4-d] pyrimidine derivatives as a new class of ATR inhibitors.

Chen P, Bin H, Jiao Y, Lin G, Zhang Y, Xia A, Pan Z, Qiao J, Guo Y, Liu J, Zhou Y, Li L. Chen P, et al. Among authors: xia a. Bioorg Med Chem Lett. 2022 May 1;63:128651. doi: 10.1016/j.bmcl.2022.128651. Epub 2022 Mar 1. Bioorg Med Chem Lett. 2022. PMID: 35245663

8

An orally available M^pro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron.

Quan BX, Shuai H, Xia AJ, Hou Y, Zeng R, Liu XL, Lin GF, Qiao JX, Li WP, Wang FL, Wang K, Zhou RJ, Yuen TT, Chen MX, Yoon C, Wu M, Zhang SY, Huang C, Wang YF, Yang W, Tian C, Li WM, Wei YQ, Yuen KY, Chan JF, Lei J, Chu H, Yang S. Quan BX, et al. Nat Microbiol. 2022 May;7(5):716-725. doi: 10.1038/s41564-022-01119-7. Epub 2022 Apr 27. Nat Microbiol. 2022. PMID: 35477751

9

Discovery of a potent, selective and cell active inhibitor of m⁶A demethylase ALKBH5.

Fang Z, Mu B, Liu Y, Guo N, Xiong L, Guo Y, Xia A, Zhang R, Zhang H, Yao R, Fan Y, Li L, Yang S, Xiang R. Fang Z, et al. Among authors: xia a. Eur J Med Chem. 2022 Aug 5;238:114446. doi: 10.1016/j.ejmech.2022.114446. Epub 2022 May 11. Eur J Med Chem. 2022. PMID: 35597008

10

Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1.

Yang X, Wang X, Xu Z, Wu C, Zhou Y, Wang Y, Lin G, Li K, Wu M, Xia A, Liu J, Cheng L, Zou J, Yan W, Shao Z, Yang S. Yang X, et al. Among authors: xia a. Nat Chem Biol. 2022 Aug;18(8):831-840. doi: 10.1038/s41589-022-01038-y. Epub 2022 May 30. Nat Chem Biol. 2022. PMID: 35637350

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