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Mitoxantrone, pixantrone and mitoxantrone (2-hydroxyethyl)piperazine are toll-like receptor 4 antagonists, inhibit NF-κB activation, and decrease TNF-alpha secretion in primary microglia.
Rinne M, Mätlik K, Ahonen T, Vedovi F, Zappia G, Moreira VM, Yli-Kauhaluoma J, Leino S, Salminen O, Kalso E, Airavaara M, Xhaard H. Rinne M, et al. Among authors: xhaard h. Eur J Pharm Sci. 2020 Nov 1;154:105493. doi: 10.1016/j.ejps.2020.105493. Epub 2020 Jul 27. Eur J Pharm Sci. 2020. PMID: 32730846 Free article.
Impact of probe compound in MRP2 vesicular transport assays.
Kidron H, Wissel G, Manevski N, Häkli M, Ketola RA, Finel M, Yliperttula M, Xhaard H, Urtti A. Kidron H, et al. Among authors: xhaard h. Eur J Pharm Sci. 2012 May 12;46(1-2):100-5. doi: 10.1016/j.ejps.2012.02.016. Epub 2012 Mar 3. Eur J Pharm Sci. 2012. PMID: 22406294
A structure-activity relationship study of ABCC2 inhibitors.
Wissel G, Deng F, Kudryavtsev P, Ghemtio L, Wipf P, Xhaard H, Kidron H. Wissel G, et al. Among authors: xhaard h. Eur J Pharm Sci. 2017 May 30;103:60-69. doi: 10.1016/j.ejps.2017.02.005. Epub 2017 Feb 7. Eur J Pharm Sci. 2017. PMID: 28185990 Free PMC article.
Adenosine analogs bearing phosphate isosteres as human MDO1 ligands.
Zhang Y, Jumppanen M, Maksimainen MM, Auno S, Awol Z, Ghemtio L, Venkannagari H, Lehtiö L, Yli-Kauhaluoma J, Xhaard H, Boije Af Gennäs G. Zhang Y, et al. Among authors: xhaard h. Bioorg Med Chem. 2018 May 1;26(8):1588-1597. doi: 10.1016/j.bmc.2018.02.006. Epub 2018 Feb 13. Bioorg Med Chem. 2018. PMID: 29501416
Azulene-based compounds for targeting orexin receptors.
Leino TO, Turku A, Yli-Kauhaluoma J, Kukkonen JP, Xhaard H, Wallén EAA. Leino TO, et al. Among authors: xhaard h. Eur J Med Chem. 2018 Sep 5;157:88-100. doi: 10.1016/j.ejmech.2018.07.040. Epub 2018 Jul 20. Eur J Med Chem. 2018. PMID: 30077889
58 results