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De novo design of tyrosine and serine kinase-driven protein switches.
Woodall NB, Weinberg Z, Park J, Busch F, Johnson RS, Feldbauer MJ, Murphy M, Ahlrichs M, Yousif I, MacCoss MJ, Wysocki VH, El-Samad H, Baker D. Woodall NB, et al. Among authors: wysocki vh. Nat Struct Mol Biol. 2021 Sep;28(9):762-770. doi: 10.1038/s41594-021-00649-8. Epub 2021 Sep 13. Nat Struct Mol Biol. 2021. PMID: 34518698 Free PMC article.
Evolutionary diversification of protein-protein interactions by interface add-ons.
Plach MG, Semmelmann F, Busch F, Busch M, Heizinger L, Wysocki VH, Merkl R, Sterner R. Plach MG, et al. Among authors: wysocki vh. Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8333-E8342. doi: 10.1073/pnas.1707335114. Epub 2017 Sep 18. Proc Natl Acad Sci U S A. 2017. PMID: 28923934 Free PMC article.
Human Argonaute3 has slicer activity.
Park MS, Phan HD, Busch F, Hinckley SH, Brackbill JA, Wysocki VH, Nakanishi K. Park MS, et al. Among authors: wysocki vh. Nucleic Acids Res. 2017 Nov 16;45(20):11867-11877. doi: 10.1093/nar/gkx916. Nucleic Acids Res. 2017. PMID: 29040713 Free PMC article.
How many human proteoforms are there?
Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, Ivanov AR, Jensen ON, Jewett MC, Kelleher NL, Kiessling LL, Krogan NJ, Larsen MR, Loo JA, Ogorzalek Loo RR, Lundberg E, MacCoss MJ, Mallick P, Mootha VK, Mrksich M, Muir TW, Patrie SM, Pesavento JJ, Pitteri SJ, Rodriguez H, Saghatelian A, Sandoval W, Schlüter H, Sechi S, Slavoff SA, Smith LM, Snyder MP, Thomas PM, Uhlén M, Van Eyk JE, Vidal M, Walt DR, White FM, Williams ER, Wohlschlager T, Wysocki VH, Yates NA, Young NL, Zhang B. Aebersold R, et al. Among authors: wysocki vh. Nat Chem Biol. 2018 Feb 14;14(3):206-214. doi: 10.1038/nchembio.2576. Nat Chem Biol. 2018. PMID: 29443976 Free PMC article.
Programmable design of orthogonal protein heterodimers.
Chen Z, Boyken SE, Jia M, Busch F, Flores-Solis D, Bick MJ, Lu P, VanAernum ZL, Sahasrabuddhe A, Langan RA, Bermeo S, Brunette TJ, Mulligan VK, Carter LP, DiMaio F, Sgourakis NG, Wysocki VH, Baker D. Chen Z, et al. Among authors: wysocki vh. Nature. 2019 Jan;565(7737):106-111. doi: 10.1038/s41586-018-0802-y. Epub 2018 Dec 19. Nature. 2019. PMID: 30568301 Free PMC article.
De novo design of tunable, pH-driven conformational changes.
Boyken SE, Benhaim MA, Busch F, Jia M, Bick MJ, Choi H, Klima JC, Chen Z, Walkey C, Mileant A, Sahasrabuddhe A, Wei KY, Hodge EA, Byron S, Quijano-Rubio A, Sankaran B, King NP, Lippincott-Schwartz J, Wysocki VH, Lee KK, Baker D. Boyken SE, et al. Among authors: wysocki vh. Science. 2019 May 17;364(6441):658-664. doi: 10.1126/science.aav7897. Science. 2019. PMID: 31097662 Free PMC article.
Light Regulation of Enzyme Allostery through Photo-responsive Unnatural Amino Acids.
Kneuttinger AC, Straub K, Bittner P, Simeth NA, Bruckmann A, Busch F, Rajendran C, Hupfeld E, Wysocki VH, Horinek D, König B, Merkl R, Sterner R. Kneuttinger AC, et al. Among authors: wysocki vh. Cell Chem Biol. 2019 Nov 21;26(11):1501-1514.e9. doi: 10.1016/j.chembiol.2019.08.006. Epub 2019 Sep 5. Cell Chem Biol. 2019. PMID: 31495713 Free PMC article.
238 results