Wypych J - Search Results

1

State-of-the-art and emerging trends in analytical approaches to pharmaceutical-product commercialization.

Blue LE, Guan X, Joubert MK, Kuhns ST, Moore S, Semin DJ, Wikström M, Wypych J, Goudar CT. Blue LE, et al. Among authors: wypych j. Curr Opin Biotechnol. 2022 Dec;78:102800. doi: 10.1016/j.copbio.2022.102800. Epub 2022 Sep 28. Curr Opin Biotechnol. 2022. PMID: 36182871 Review.

2

Classification and characterization of therapeutic antibody aggregates.

Joubert MK, Luo Q, Nashed-Samuel Y, Wypych J, Narhi LO. Joubert MK, et al. Among authors: wypych j. J Biol Chem. 2011 Jul 15;286(28):25118-33. doi: 10.1074/jbc.M110.160457. Epub 2011 Mar 25. J Biol Chem. 2011. PMID: 21454532 Free PMC article.

Chemical modifications were also identified in a separate report (Luo, Q., Joubert, M. K., Stevenson, R., Narhi, L. O., and Wypych, J. (2011) J. Biol. Chem. 286, 25134-25144). Aggregates were categorized into seven discrete classes, based on the traits descri …

Chemical modifications were also identified in a separate report (Luo, Q., Joubert, M. K., Stevenson, R., Narhi, L. O., and Wypych, …

3

Chemical modifications in therapeutic protein aggregates generated under different stress conditions.

Luo Q, Joubert MK, Stevenson R, Ketchem RR, Narhi LO, Wypych J. Luo Q, et al. Among authors: wypych j. J Biol Chem. 2011 Jul 15;286(28):25134-44. doi: 10.1074/jbc.M110.160440. Epub 2011 Apr 25. J Biol Chem. 2011. PMID: 21518762 Free PMC article.

In a separate study, additional biophysical characterization was performed to arrange these aggregates into a classification system (Joubert, M. K., Luo, Q., Nashed-Samuel, Y., Wypych, J., and Narhi, L. O. (2011) J. Biol. Chem. 286, 25118-25133). ...

In a separate study, additional biophysical characterization was performed to arrange these aggregates into a classification system (Joubert …

4

Development of a human antibody tolerant mouse model to assess the immunogenicity risk due to aggregated biotherapeutics.

Bi V, Jawa V, Joubert MK, Kaliyaperumal A, Eakin C, Richmond K, Pan O, Sun J, Hokom M, Goletz TJ, Wypych J, Zhou L, Kerwin BA, Narhi LO, Arora T. Bi V, et al. Among authors: wypych j. J Pharm Sci. 2013 Oct;102(10):3545-55. doi: 10.1002/jps.23663. Epub 2013 Aug 7. J Pharm Sci. 2013. PMID: 23925953

5

Structural Characterization of a Monoclonal Antibody-Maytansinoid Immunoconjugate.

Luo Q, Chung HH, Borths C, Janson M, Wen J, Joubert MK, Wypych J. Luo Q, et al. Among authors: wypych j. Anal Chem. 2016 Jan 5;88(1):695-702. doi: 10.1021/acs.analchem.5b03709. Epub 2015 Dec 14. Anal Chem. 2016. PMID: 26629796

6

Chemical and Biophysical Characteristics of Monoclonal Antibody Solutions Containing Aggregates Formed during Metal Catalyzed Oxidation.

Narhi LO, Luo Q, Wypych J, Torosantucci R, Hawe A, Fujimori K, Nashed-Samuel Y, Jawa V, Joubert MK, Jiskoot W. Narhi LO, et al. Among authors: wypych j. Pharm Res. 2017 Dec;34(12):2817-2828. doi: 10.1007/s11095-017-2262-8. Epub 2017 Nov 6. Pharm Res. 2017. PMID: 29110285

7

Direct mass spectrometric characterization of disulfide linkages.

Guan X, Zhang L, Wypych J. Guan X, et al. Among authors: wypych j. MAbs. 2018 May/Jun;10(4):572-582. doi: 10.1080/19420862.2018.1442998. Epub 2018 Mar 14. MAbs. 2018. PMID: 29469657 Free PMC article.

8

Development and Validation of a HPLC-UV Method for Urea and Related Impurities.

Woldemariam G, Kyad A, Moore S, Qiu J, Semin D, Tan ZJ, Wypych J. Woldemariam G, et al. Among authors: wypych j. PDA J Pharm Sci Technol. 2020 Jan-Feb;74(1):2-14. doi: 10.5731/pdajpst.2018.009803. Epub 2019 Jun 17. PDA J Pharm Sci Technol. 2020. PMID: 31209168

9

Observation and Mitigation of Leachables from Non-Product Contact Materials in Electromechanical Delivery Devices for Biotechnology Products.

Liu J, Ronk M, Luo Y, Wypych J, Zhang Z, Perez-Pacheco J, Jin E, Shah B, Richardson J, Li K, Semin D, Nashed-Samuel Y. Liu J, et al. Among authors: wypych j. J Pharm Sci. 2021 Dec;110(12):3794-3802. doi: 10.1016/j.xphs.2021.08.007. Epub 2021 Aug 12. J Pharm Sci. 2021. PMID: 34390741

10

A Mass Spectrometric Characterization of Light-Induced Modifications in Therapeutic Proteins.

Zhang Z, Chow SY, De Guzman R, Joh NH, Joubert MK, Richardson J, Shah B, Wikström M, Zhou ZS, Wypych J. Zhang Z, et al. Among authors: wypych j. J Pharm Sci. 2022 Jun;111(6):1556-1564. doi: 10.1016/j.xphs.2022.02.002. Epub 2022 Feb 12. J Pharm Sci. 2022. PMID: 35167884 Free article.

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