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Phenotypic screening identifies a trisubstituted imidazo[1,2-a]pyridine series that induces differentiation in multiple AML cell lines.
Josa-Culleré L, Galan SRG, Cogswell TJ, Jackson TR, Jay-Smith M, Mola L, Greaves CR, Carter TS, Madden KS, Trott S, Zhang D, Bataille CJR, Davies SG, Vyas P, Milne TA, Naylor A, Wynne GM, Russell AJ. Josa-Culleré L, et al. Among authors: wynne gm. Eur J Med Chem. 2023 Oct 5;258:115509. doi: 10.1016/j.ejmech.2023.115509. Epub 2023 May 26. Eur J Med Chem. 2023. PMID: 37343464
A Phenotypic Screen Identifies a Compound Series That Induces Differentiation of Acute Myeloid Leukemia Cells In Vitro and Shows Antitumor Effects In Vivo.
Josa-Culleré L, Madden KS, Cogswell TJ, Jackson TR, Carter TS, Zhang D, Trevitt G, Davies SG, Vyas P, Wynne GM, Milne TA, Russell AJ. Josa-Culleré L, et al. Among authors: wynne gm. J Med Chem. 2021 Nov 11;64(21):15608-15628. doi: 10.1021/acs.jmedchem.1c00574. Epub 2021 Oct 21. J Med Chem. 2021. PMID: 34672555 Free article.
Stemistry: the control of stem cells in situ using chemistry.
Davies SG, Kennewell PD, Russell AJ, Seden PT, Westwood R, Wynne GM. Davies SG, et al. Among authors: wynne gm. J Med Chem. 2015 Apr 9;58(7):2863-94. doi: 10.1021/jm500838d. Epub 2015 Jan 15. J Med Chem. 2015. PMID: 25590360 Review.
Thiazolidine derivatives as potent and selective inhibitors of the PIM kinase family.
Bataille CJ, Brennan MB, Byrne S, Davies SG, Durbin M, Fedorov O, Huber KV, Jones AM, Knapp S, Liu G, Nadali A, Quevedo CE, Russell AJ, Walker RG, Westwood R, Wynne GM. Bataille CJ, et al. Among authors: wynne gm. Bioorg Med Chem. 2017 May 1;25(9):2657-2665. doi: 10.1016/j.bmc.2017.02.056. Epub 2017 Feb 28. Bioorg Med Chem. 2017. PMID: 28341403 Free article.
Aminothiazolones as potent, selective and cell active inhibitors of the PIM kinase family.
Quevedo CE, Bataille CJR, Byrne S, Durbin M, Elkins J, Guillermo A, Jones AM, Knapp S, Nadali A, Walker RG, Wilkinson IVL, Wynne GM, Davies SG, Russell AJ. Quevedo CE, et al. Among authors: wynne gm. Bioorg Med Chem. 2020 Nov 15;28(22):115724. doi: 10.1016/j.bmc.2020.115724. Epub 2020 Aug 26. Bioorg Med Chem. 2020. PMID: 33128909
Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy.
Vuorinen A, Wilkinson IVL, Chatzopoulou M, Edwards B, Squire SE, Fairclough RJ, Bazan NA, Milner JA, Conole D, Donald JR, Shah N, Willis NJ, Martínez RF, Wilson FX, Wynne GM, Davies SG, Davies KE, Russell AJ. Vuorinen A, et al. Among authors: wynne gm. Eur J Med Chem. 2021 Aug 5;220:113431. doi: 10.1016/j.ejmech.2021.113431. Epub 2021 Apr 20. Eur J Med Chem. 2021. PMID: 33915371
Identification and Preliminary Structure-Activity Relationship Studies of 1,5-Dihydrobenzo[e][1,4]oxazepin-2(3H)-ones That Induce Differentiation of Acute Myeloid Leukemia Cells In Vitro.
Josa-Culleré L, Cogswell TJ, Georgiou I, Jay-Smith M, Jackson TR, Bataille CJR, Davies SG, Vyas P, Milne TA, Wynne GM, Russell AJ. Josa-Culleré L, et al. Among authors: wynne gm. Molecules. 2021 Nov 2;26(21):6648. doi: 10.3390/molecules26216648. Molecules. 2021. PMID: 34771052 Free PMC article.
Pilot Study to Quantify Palladium Impurities in Lead-like Compounds Following Commonly Used Purification Techniques.
Chatzopoulou M, Madden KS, Bromhead LJ, Greaves C, Cogswell TJ, Da Silva Pinto S, Galan SRG, Georgiou I, Kennedy MS, Kennett A, Apps G, Russell AJ, Wynne GM. Chatzopoulou M, et al. Among authors: wynne gm. ACS Med Chem Lett. 2022 Jan 20;13(2):262-270. doi: 10.1021/acsmedchemlett.1c00638. eCollection 2022 Feb 10. ACS Med Chem Lett. 2022. PMID: 35173892 Free PMC article.
A tubulin binding molecule drives differentiation of acute myeloid leukemia cells.
Jackson TR, Vuorinen A, Josa-Culleré L, Madden KS, Conole D, Cogswell TJ, Wilkinson IVL, Kettyle LM, Zhang D, O'Mahony A, Gracias D, McCall L, Westwood R, Terstappen GC, Davies SG, Tate EW, Wynne GM, Vyas P, Russell AJ, Milne TA. Jackson TR, et al. Among authors: wynne gm. iScience. 2022 Jul 19;25(8):104787. doi: 10.1016/j.isci.2022.104787. eCollection 2022 Aug 19. iScience. 2022. PMID: 35992086 Free PMC article.
35 results