Wymore T - Search Results

1

Exploring the physicochemical properties of oxime-reactivation therapeutics for cyclosarin, sarin, tabun, and VX inactivated acetylcholinesterase.

Esposito EX, Stouch TR, Wymore T, Madura JD. Esposito EX, et al. Among authors: wymore t. Chem Res Toxicol. 2014 Jan 21;27(1):99-110. doi: 10.1021/tx400350b. Epub 2014 Jan 9. Chem Res Toxicol. 2014. PMID: 24443939

2

Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase.

Gerlits O, Kong X, Cheng X, Wymore T, Blumenthal DK, Taylor P, Radić Z, Kovalevsky A. Gerlits O, et al. Among authors: wymore t. J Biol Chem. 2019 Jul 5;294(27):10607-10618. doi: 10.1074/jbc.RA119.008725. Epub 2019 May 28. J Biol Chem. 2019. PMID: 31138650 Free PMC article.

3

L-Arabinose binding, isomerization, and epimerization by D-xylose isomerase: X-ray/neutron crystallographic and molecular simulation study.

Langan P, Sangha AK, Wymore T, Parks JM, Yang ZK, Hanson BL, Fisher Z, Mason SA, Blakeley MP, Forsyth VT, Glusker JP, Carrell HL, Smith JC, Keen DA, Graham DE, Kovalevsky A. Langan P, et al. Among authors: wymore t. Structure. 2014 Sep 2;22(9):1287-1300. doi: 10.1016/j.str.2014.07.002. Epub 2014 Aug 14. Structure. 2014. PMID: 25132082 Free article.

4

Long-Range Electrostatics-Induced Two-Proton Transfer Captured by Neutron Crystallography in an Enzyme Catalytic Site.

Gerlits O, Wymore T, Das A, Shen CH, Parks JM, Smith JC, Weiss KL, Keen DA, Blakeley MP, Louis JM, Langan P, Weber IT, Kovalevsky A. Gerlits O, et al. Among authors: wymore t. Angew Chem Int Ed Engl. 2016 Apr 11;55(16):4924-7. doi: 10.1002/anie.201509989. Epub 2016 Mar 9. Angew Chem Int Ed Engl. 2016. PMID: 26958828 Free PMC article.

5

Homolytic Cleavage of Both Heme-Bound Hydrogen Peroxide and Hydrogen Sulfide Leads to the Formation of Sulfheme.

Arbelo-Lopez HD, Simakov NA, Smith JC, Lopez-Garriga J, Wymore T. Arbelo-Lopez HD, et al. Among authors: wymore t. J Phys Chem B. 2016 Aug 4;120(30):7319-31. doi: 10.1021/acs.jpcb.6b02839. Epub 2016 Jul 22. J Phys Chem B. 2016. PMID: 27357070

6

Neutron scattering in the biological sciences: progress and prospects.

Ashkar R, Bilheux HZ, Bordallo H, Briber R, Callaway DJE, Cheng X, Chu XQ, Curtis JE, Dadmun M, Fenimore P, Fushman D, Gabel F, Gupta K, Herberle F, Heinrich F, Hong L, Katsaras J, Kelman Z, Kharlampieva E, Kneller GR, Kovalevsky A, Krueger S, Langan P, Lieberman R, Liu Y, Losche M, Lyman E, Mao Y, Marino J, Mattos C, Meilleur F, Moody P, Nickels JD, O'Dell WB, O'Neill H, Perez-Salas U, Peters J, Petridis L, Sokolov AP, Stanley C, Wagner N, Weinrich M, Weiss K, Wymore T, Zhang Y, Smith JC. Ashkar R, et al. Among authors: wymore t. Acta Crystallogr D Struct Biol. 2018 Dec 1;74(Pt 12):1129-1168. doi: 10.1107/S2059798318017503. Epub 2018 Dec 20. Acta Crystallogr D Struct Biol. 2018. PMID: 30605130

7

Visualizing Tetrahedral Oxyanion Bound in HIV-1 Protease Using Neutrons: Implications for the Catalytic Mechanism and Drug Design.

Kumar M, Mandal K, Blakeley MP, Wymore T, Kent SBH, Louis JM, Das A, Kovalevsky A. Kumar M, et al. Among authors: wymore t. ACS Omega. 2020 May 14;5(20):11605-11617. doi: 10.1021/acsomega.0c00835. eCollection 2020 May 26. ACS Omega. 2020. PMID: 32478251 Free PMC article.

8

Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis.

Wan Q, Bennett BC, Wymore T, Li Z, Wilson MA, Brooks CL 3rd, Langan P, Kovalevsky A, Dealwis CG. Wan Q, et al. Among authors: wymore t. ACS Catal. 2021 May 7;11(9):5873-5884. doi: 10.1021/acscatal.1c00417. Epub 2021 Apr 28. ACS Catal. 2021. PMID: 34055457 Free PMC article.

9

Hydrolysis of DFP and the nerve agent (S)-sarin by DFPase proceeds along two different reaction pathways: implications for engineering bioscavengers.

Wymore T, Field MJ, Langan P, Smith JC, Parks JM. Wymore T, et al. J Phys Chem B. 2014 May 1;118(17):4479-89. doi: 10.1021/jp410422c. Epub 2014 Apr 21. J Phys Chem B. 2014. PMID: 24720808 Free PMC article.

10

A Distal Disulfide Bridge in OXA-1 β-Lactamase Stabilizes the Catalytic Center and Alters the Dynamics of the Specificity Determining Ω Loop.

Simakov N, Leonard DA, Smith JC, Wymore T, Szarecka A. Simakov N, et al. Among authors: wymore t. J Phys Chem B. 2017 Apr 20;121(15):3285-3296. doi: 10.1021/acs.jpcb.6b07884. Epub 2016 Oct 7. J Phys Chem B. 2017. PMID: 27668669

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