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Page 1
Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei.
Wyllie S, Foth BJ, Kelner A, Sokolova AY, Berriman M, Fairlamb AH. Wyllie S, et al. J Antimicrob Chemother. 2016 Mar;71(3):625-34. doi: 10.1093/jac/dkv376. Epub 2015 Nov 17. J Antimicrob Chemother. 2016. PMID: 26581221 Free PMC article.
Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.
Field MC, Horn D, Fairlamb AH, Ferguson MA, Gray DW, Read KD, De Rycker M, Torrie LS, Wyatt PG, Wyllie S, Gilbert IH. Field MC, et al. Among authors: wyllie s. Nat Rev Microbiol. 2017 Feb 27;15(4):217-231. doi: 10.1038/nrmicro.2016.193. Online ahead of print. Nat Rev Microbiol. 2017. PMID: 28239154 Free PMC article. Review.
Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals.
Wall RJ, Moniz S, Thomas MG, Norval S, Ko EJ, Marco M, Miles TJ, Gilbert IH, Horn D, Fairlamb AH, Wyllie S. Wall RJ, et al. Among authors: wyllie s. Antimicrob Agents Chemother. 2018 Jul 27;62(8):e00235-18. doi: 10.1128/AAC.00235-18. Print 2018 Aug. Antimicrob Agents Chemother. 2018. PMID: 29844044 Free PMC article.
Clinical and veterinary trypanocidal benzoxaboroles target CPSF3.
Wall RJ, Rico E, Lukac I, Zuccotto F, Elg S, Gilbert IH, Freund Y, Alley MRK, Field MC, Wyllie S, Horn D. Wall RJ, et al. Among authors: wyllie s. Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9616-9621. doi: 10.1073/pnas.1807915115. Epub 2018 Sep 5. Proc Natl Acad Sci U S A. 2018. PMID: 30185555 Free PMC article.
Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani.
Corpas-Lopez V, Moniz S, Thomas M, Wall RJ, Torrie LS, Zander-Dinse D, Tinti M, Brand S, Stojanovski L, Manthri S, Hallyburton I, Zuccotto F, Wyatt PG, De Rycker M, Horn D, Ferguson MAJ, Clos J, Read KD, Fairlamb AH, Gilbert IH, Wyllie S. Corpas-Lopez V, et al. Among authors: wyllie s. ACS Infect Dis. 2019 Jan 11;5(1):111-122. doi: 10.1021/acsinfecdis.8b00226. Epub 2018 Nov 12. ACS Infect Dis. 2019. PMID: 30380837 Free PMC article.
Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Wyllie S, Brand S, Thomas M, De Rycker M, Chung CW, Pena I, Bingham RP, Bueren-Calabuig JA, Cantizani J, Cebrian D, Craggs PD, Ferguson L, Goswami P, Hobrath J, Howe J, Jeacock L, Ko EJ, Korczynska J, MacLean L, Manthri S, Martinez MS, Mata-Cantero L, Moniz S, Nühs A, Osuna-Cabello M, Pinto E, Riley J, Robinson S, Rowland P, Simeons FRC, Shishikura Y, Spinks D, Stojanovski L, Thomas J, Thompson S, Viayna Gaza E, Wall RJ, Zuccotto F, Horn D, Ferguson MAJ, Fairlamb AH, Fiandor JM, Martin J, Gray DW, Miles TJ, Gilbert IH, Read KD, Marco M, Wyatt PG. Wyllie S, et al. Proc Natl Acad Sci U S A. 2019 May 7;116(19):9318-9323. doi: 10.1073/pnas.1820175116. Epub 2019 Apr 8. Proc Natl Acad Sci U S A. 2019. PMID: 30962368 Free PMC article.
Setting Our Sights on Infectious Diseases.
De Rycker M, Horn D, Aldridge B, Amewu RK, Barry CE 3rd, Buckner FS, Cook S, Ferguson MAJ, Gobeau N, Herrmann J, Herrling P, Hope W, Keiser J, Lafuente-Monasterio MJ, Leeson PD, Leroy D, Manjunatha UH, McCarthy J, Miles TJ, Mizrahi V, Moshynets O, Niles J, Overington JP, Pottage J, Rao SPS, Read KD, Ribeiro I, Silver LL, Southern J, Spangenberg T, Sundar S, Taylor C, Van Voorhis W, White NJ, Wyllie S, Wyatt PG, Gilbert IH. De Rycker M, et al. Among authors: wyllie s. ACS Infect Dis. 2020 Jan 10;6(1):3-13. doi: 10.1021/acsinfecdis.9b00371. Epub 2019 Dec 6. ACS Infect Dis. 2020. PMID: 31808676 Free PMC article.
168 results