Wyllie DJA - Search Results

1

Loss of cerebellar glutamate transporters EAAT4 and GLAST differentially affects the spontaneous firing pattern and survival of Purkinje cells.

Perkins EM, Clarkson YL, Suminaite D, Lyndon AR, Tanaka K, Rothstein JD, Skehel PA, Wyllie DJA, Jackson M. Perkins EM, et al. Among authors: wyllie dja. Hum Mol Genet. 2018 Aug 1;27(15):2614-2627. doi: 10.1093/hmg/ddy169. Hum Mol Genet. 2018. PMID: 29741614 Free PMC article.

2

The neuroprotective WldS gene regulates expression of PTTG1 and erythroid differentiation regulator 1-like gene in mice and human cells.

Gillingwater TH, Wishart TM, Chen PE, Haley JE, Robertson K, MacDonald SH, Middleton S, Wawrowski K, Shipston MJ, Melmed S, Wyllie DJ, Skehel PA, Coleman MP, Ribchester RR. Gillingwater TH, et al. Hum Mol Genet. 2006 Feb 15;15(4):625-35. doi: 10.1093/hmg/ddi478. Epub 2006 Jan 10. Hum Mol Genet. 2006. PMID: 16403805

3

Loss of beta-III spectrin leads to Purkinje cell dysfunction recapitulating the behavior and neuropathology of spinocerebellar ataxia type 5 in humans.

Perkins EM, Clarkson YL, Sabatier N, Longhurst DM, Millward CP, Jack J, Toraiwa J, Watanabe M, Rothstein JD, Lyndon AR, Wyllie DJ, Dutia MB, Jackson M. Perkins EM, et al. J Neurosci. 2010 Apr 7;30(14):4857-67. doi: 10.1523/JNEUROSCI.6065-09.2010. J Neurosci. 2010. PMID: 20371805 Free PMC article.

4

Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals.

Qiu J, Tan YW, Hagenston AM, Martel MA, Kneisel N, Skehel PA, Wyllie DJ, Bading H, Hardingham GE. Qiu J, et al. Nat Commun. 2013;4:2034. doi: 10.1038/ncomms3034. Nat Commun. 2013. PMID: 23774321 Free PMC article.

5

Conserved hippocampal cellular pathophysiology but distinct behavioural deficits in a new rat model of FXS.

Till SM, Asiminas A, Jackson AD, Katsanevaki D, Barnes SA, Osterweil EK, Bear MF, Chattarji S, Wood ER, Wyllie DJ, Kind PC. Till SM, et al. Hum Mol Genet. 2015 Nov 1;24(21):5977-84. doi: 10.1093/hmg/ddv299. Epub 2015 Aug 4. Hum Mol Genet. 2015. PMID: 26243794 Free PMC article.

6

Effect of a GRIN2A de novo mutation associated with epilepsy and intellectual disability on NMDA receptor currents and Mg(2+) block in cultured primary cortical neurons.

Marwick K, Skehel P, Hardingham G, Wyllie D. Marwick K, et al. Lancet. 2015 Feb 26;385 Suppl 1:S65. doi: 10.1016/S0140-6736(15)60380-4. Lancet. 2015. PMID: 26312887

7

Posterior cerebellar Purkinje cells in an SCA5/SPARCA1 mouse model are especially vulnerable to the synergistic effect of loss of β-III spectrin and GLAST.

Perkins EM, Suminaite D, Clarkson YL, Lee SK, Lyndon AR, Rothstein JD, Wyllie DJ, Tanaka K, Jackson M. Perkins EM, et al. Hum Mol Genet. 2016 Oct 15;25(20):4448-4461. doi: 10.1093/hmg/ddw274. Hum Mol Genet. 2016. PMID: 28173092 Free PMC article.

8

Functional assessment of the NMDA receptor variant GluN2A ^R586K.

Marwick KFM, Parker P, Skehel P, Hardingham G, Wyllie DJA. Marwick KFM, et al. Among authors: wyllie dja. Wellcome Open Res. 2017 Mar 17;2:20. doi: 10.12688/wellcomeopenres.10985.2. Wellcome Open Res. 2017. PMID: 28459106 Free PMC article.

9

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca²⁺-permeable AMPA receptor-mediated excitotoxicity.

Selvaraj BT, Livesey MR, Zhao C, Gregory JM, James OT, Cleary EM, Chouhan AK, Gane AB, Perkins EM, Dando O, Lillico SG, Lee YB, Nishimura AL, Poreci U, Thankamony S, Pray M, Vasistha NA, Magnani D, Borooah S, Burr K, Story D, McCampbell A, Shaw CE, Kind PC, Aitman TJ, Whitelaw CBA, Wilmut I, Smith C, Miles GB, Hardingham GE, Wyllie DJA, Chandran S. Selvaraj BT, et al. Among authors: wyllie dja. Nat Commun. 2018 Jan 24;9(1):347. doi: 10.1038/s41467-017-02729-0. Nat Commun. 2018. PMID: 29367641 Free PMC article.

10

GRIN2A-related disorders: genotype and functional consequence predict phenotype.

Strehlow V, Heyne HO, Vlaskamp DRM, Marwick KFM, Rudolf G, de Bellescize J, Biskup S, Brilstra EH, Brouwer OF, Callenbach PMC, Hentschel J, Hirsch E, Kind PC, Mignot C, Platzer K, Rump P, Skehel PA, Wyllie DJA, Hardingham GE, van Ravenswaaij-Arts CMA, Lesca G, Lemke JR; GRIN2A study group. Strehlow V, et al. Among authors: wyllie dja. Brain. 2019 Jan 1;142(1):80-92. doi: 10.1093/brain/awy304. Brain. 2019. PMID: 30544257 Free PMC article.

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