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Page 1
Generation and multiomic profiling of a TP53/CDKN2A double-knockout gastroesophageal junction organoid model.
Zhao H, Cheng Y, Kalra A, Ma K, Zheng Y, Ziman B, Tressler C, Glunde K, Shin EJ, Ngamruengphong S, Khashab M, Singh V, Anders RA, Jit S, Wyhs N, Chen W, Li X, Lin DC, Meltzer SJ. Zhao H, et al. Among authors: wyhs n. Sci Transl Med. 2022 Nov 30;14(673):eabq6146. doi: 10.1126/scitranslmed.abq6146. Epub 2022 Nov 30. Sci Transl Med. 2022. PMID: 36449602 Free PMC article.
An isogenic cell line panel for sequence-based screening of targeted anticancer drugs.
Cook AL, Wyhs N, Sur S, Ptak B, Popoli M, Dobbyn L, Papadopoulos T, Bettegowda C, Papadopoulos N, Vogelstein B, Zhou S, Kinzler KW. Cook AL, et al. Among authors: wyhs n. iScience. 2022 May 23;25(6):104437. doi: 10.1016/j.isci.2022.104437. eCollection 2022 Jun 17. iScience. 2022. PMID: 35692635 Free PMC article.
Phenotypic characterization of two novel cell line models of castration-resistant prostate cancer.
Haffner MC, Bhamidipati A, Tsai HK, Esopi DM, Vaghasia AM, Low JY, Patel RA, Guner G, Pham MT, Castagna N, Hicks J, Wyhs N, Aebersold R, De Marzo AM, Nelson WG, Guo T, Yegnasubramanian S. Haffner MC, et al. Among authors: wyhs n. Prostate. 2021 Nov;81(15):1159-1171. doi: 10.1002/pros.24210. Epub 2021 Aug 16. Prostate. 2021. PMID: 34402095 Free PMC article.
AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination.
Haffner MC, Esopi DM, Chaux A, Gürel M, Ghosh S, Vaghasia AM, Tsai H, Kim K, Castagna N, Lam H, Hicks J, Wyhs N, Biswal Shinohara D, Hurley PJ, Simons BW, Schaeffer EM, Lotan TL, Isaacs WB, Netto GJ, De Marzo AM, Nelson WG, An SS, Yegnasubramanian S. Haffner MC, et al. Among authors: wyhs n. Nat Commun. 2017 Jul 26;8(1):142. doi: 10.1038/s41467-017-00084-8. Nat Commun. 2017. PMID: 28747635 Free PMC article.
Personalized postdoctoral fellowship care.
Graham MK, Park BH, Wyhs N. Graham MK, et al. Among authors: wyhs n. Nat Biotechnol. 2018 Sep 6;36(9):900-902. doi: 10.1038/nbt.4228. Nat Biotechnol. 2018. PMID: 30188527 No abstract available.
A high-throughput screen of pharmacologically active compounds for inhibitors of UHRF1 reveals epigenetic activity of anthracycline derivative chemotherapeutic drugs.
Giovinazzo H, Walker D, Wyhs N, Liu J, Esopi DM, Vaghasia AM, Jain Y, Bhamidipati A, Zhou J, Nelson WG, Yegnasubramanian S. Giovinazzo H, et al. Among authors: wyhs n. Oncotarget. 2019 Apr 30;10(32):3040-3050. doi: 10.18632/oncotarget.26889. eCollection 2019 Apr 30. Oncotarget. 2019. PMID: 31105884 Free PMC article.
TRBC1-targeting antibody-drug conjugates for the treatment of T cell cancers.
Nichakawade TD, Ge J, Mog BJ, Lee BS, Pearlman AH, Hwang MS, DiNapoli SR, Wyhs N, Marcou N, Glavaris S, Konig MF, Gabelli SB, Watson E, Sterling C, Wagner-Johnston N, Rozati S, Swinnen L, Fuchs E, Pardoll DM, Gabrielson K, Papadopoulos N, Bettegowda C, Kinzler KW, Zhou S, Sur S, Vogelstein B, Paul S. Nichakawade TD, et al. Among authors: wyhs n. Nature. 2024 Apr;628(8007):416-423. doi: 10.1038/s41586-024-07233-2. Epub 2024 Mar 27. Nature. 2024. PMID: 38538786
Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape.
Cook AL, Sur S, Dobbyn L, Watson E, Cohen JD, Ptak B, Lee BS, Paul S, Hsiue E, Popoli M, Vogelstein B, Papadopoulos N, Bettegowda C, Gabrielson K, Zhou S, Kinzler KW, Wyhs N. Cook AL, et al. Among authors: wyhs n. bioRxiv [Preprint]. 2023 Dec 29:2023.12.28.573594. doi: 10.1101/2023.12.28.573594. bioRxiv. 2023. PMID: 38234817 Free PMC article. Preprint.
12 results