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Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity.
Schmidt H, Raj T, O'Neill TJ, Muschaweckh A, Giesert F, Negraschus A, Hoefig KP, Behrens G, Esser L, Baumann C, Feederle R, Plaza-Sirvent C, Geerlof A, Gewies A, Isay SE, Ruland J, Schmitz I, Wurst W, Korn T, Krappmann D, Heissmeyer V. Schmidt H, et al. Among authors: wurst w. Proc Natl Acad Sci U S A. 2023 Nov 28;120(48):e2309205120. doi: 10.1073/pnas.2309205120. Epub 2023 Nov 21. Proc Natl Acad Sci U S A. 2023. PMID: 37988467 Free PMC article.
Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein.
Dening Y, Straßl T, Ruf V, Dirscherl P, Chovsepian A, Stievenard A, Khairnar A, Schmidt F, Giesert F, Herms J, Levin J, Dieterich M, Falkai P, Weisenhorn DV, Wurst W, Giese A, Pan-Montojo F. Dening Y, et al. Among authors: wurst w. Sci Rep. 2022 Dec 19;12(1):21951. doi: 10.1038/s41598-022-25790-2. Sci Rep. 2022. PMID: 36535974 Free PMC article.
Genome-wide screening reveals the genetic basis of mammalian embryonic eye development.
Chee JM, Lanoue L, Clary D, Higgins K, Bower L, Flenniken A, Guo R, Adams DJ, Bosch F, Braun RE, Brown SDM, Chin HG, Dickinson ME, Hsu CW, Dobbie M, Gao X, Galande S, Grobler A, Heaney JD, Herault Y, de Angelis MH, Mammano F, Nutter LMJ, Parkinson H, Qin C, Shiroishi T, Sedlacek R, Seong JK, Xu Y; International Mouse Phenotyping Consortium; Brooks B, McKerlie C, Lloyd KCK, Westerberg H, Moshiri A. Chee JM, et al. BMC Biol. 2023 Feb 3;21(1):22. doi: 10.1186/s12915-022-01475-0. BMC Biol. 2023. PMID: 36737727 Free PMC article.
Systemic deletion of DMD exon 51 rescues clinically severe Duchenne muscular dystrophy in a pig model lacking DMD exon 52.
Stirm M, Shashikadze B, Blutke A, Kemter E, Lange A, Stöckl JB, Jaudas F, Laane L, Kurome M, Keßler B, Zakhartchenko V, Bähr A, Klymiuk N, Nagashima H, Walter MC, Wurst W, Kupatt C, Fröhlich T, Wolf E. Stirm M, et al. Among authors: wurst w. Proc Natl Acad Sci U S A. 2023 Jul 18;120(29):e2301250120. doi: 10.1073/pnas.2301250120. Epub 2023 Jul 10. Proc Natl Acad Sci U S A. 2023. PMID: 37428903 Free PMC article.
AOX delays the onset of the lethal phenotype in a mouse model of Uqcrh (complex III) disease.
Jacobs HT, Szibor M, Rathkolb B, da Silva-Buttkus P, Aguilar-Pimentel JA, Amarie OV, Becker L, Calzada-Wack J, Dragano N, Garrett L, Gerlini R, Hölter SM, Klein-Rodewald T, Kraiger M, Leuchtenberger S, Marschall S, Östereicher MA, Pfannes K, Sanz-Moreno A, Seisenberger C, Spielmann N, Stoeger C, Wurst W, Fuchs H, Hrabě de Angelis M, Gailus-Durner V. Jacobs HT, et al. Among authors: wurst w. Biochim Biophys Acta Mol Basis Dis. 2023 Oct;1869(7):166760. doi: 10.1016/j.bbadis.2023.166760. Epub 2023 May 23. Biochim Biophys Acta Mol Basis Dis. 2023. PMID: 37230398 Free article.
Implication of transcription factor FOXD2 dysfunction in syndromic congenital anomalies of the kidney and urinary tract (CAKUT).
Riedhammer KM, Nguyen TT, Koşukcu C, Calzada-Wack J, Li Y, Assia Batzir N, Saygılı S, Wimmers V, Kim GJ, Chrysanthou M, Bakey Z, Sofrin-Drucker E, Kraiger M, Sanz-Moreno A, Amarie OV, Rathkolb B, Klein-Rodewald T, Garrett L, Hölter SM, Seisenberger C, Haug S, Schlosser P, Marschall S, Wurst W, Fuchs H, Gailus-Durner V, Wuttke M, Hrabe de Angelis M, Ćomić J, Akgün Doğan Ö, Özlük Y, Taşdemir M, Ağbaş A, Canpolat N, Orenstein N, Çalışkan S, Weber RG, Bergmann C, Jeanpierre C, Saunier S, Lim TY, Hildebrandt F, Alhaddad B, Basel-Salmon L, Borovitz Y, Wu K, Antony D, Matschkal J, Schaaf CW, Renders L, Schmaderer C, Rogg M, Schell C, Meitinger T, Heemann U, Köttgen A, Arnold SJ, Ozaltin F, Schmidts M, Hoefele J. Riedhammer KM, et al. Among authors: wurst w. Kidney Int. 2024 Apr;105(4):844-864. doi: 10.1016/j.kint.2023.11.032. Epub 2023 Dec 26. Kidney Int. 2024. PMID: 38154558 Free PMC article.
LncRNA U90926 is dispensable for the development of obesity-associated phenotypes in vivo.
Sabikunnahar B, Caldwell S, Varnum S, Hogan T, Lahue KG, Rathkolb B, Gerlini R, Dragano NRV, Aguilar-Pimentel A, Irmler M, Sanz-Moreno A, da Silva-Buttkus P; German Mouse Clinic Consortium; Beckers J, Wolf E, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Ather JL, Poynter ME, Krementsov DN. Sabikunnahar B, et al. Physiol Rep. 2024 Jan;12(1):e15901. doi: 10.14814/phy2.15901. Physiol Rep. 2024. PMID: 38171546 Free PMC article.
536 results