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Loss of soluble guanylyl cyclase in platelets contributes to atherosclerotic plaque formation and vascular inflammation.
Mauersberger C, Sager HB, Wobst J, Dang TA, Lambrecht L, Koplev S, Stroth M, Bettaga N, Schlossmann J, Wunder F, Friebe A, Björkegren JLM, Dietz L, Maas SL, van der Vorst EPC, Sandner P, Soehnlein O, Schunkert H, Kessler T. Mauersberger C, et al. Among authors: wunder f. Nat Cardiovasc Res. 2022 Dec;1(12):1174-1186. doi: 10.1038/s44161-022-00175-w. Epub 2022 Dec 12. Nat Cardiovasc Res. 2022. PMID: 37484062 Free PMC article.
New Generation of sGC Stimulators: Discovery of Imidazo[1,2-a]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Resistant Hypertension.
Vakalopoulos A, Wunder F, Hartung IV, Redlich G, Jautelat R, Buchgraber P, Hassfeld J, Gromov AV, Lindner N, Bierer D, Gries J, Kroh W, Paulsen H, Mittendorf J, Lang D, Becker-Pelster E, Brockschnieder D, Geiss V, Li V, Straub A, Knorr A, Mondritzki T, Trübel H, Raschke M, Schaefer M, Thomas D, Sandner P, Stasch JP, Follmann M. Vakalopoulos A, et al. Among authors: wunder f. J Med Chem. 2023 Jun 8;66(11):7280-7303. doi: 10.1021/acs.jmedchem.2c02082. Epub 2023 Apr 11. J Med Chem. 2023. PMID: 37040336
A transcriptomics approach to expand therapeutic options and optimize clinical trials in oncology.
Lazar V, Zhang B, Magidi S, Le Tourneau C, Raymond E, Ducreux M, Bresson C, Raynaud J, Wunder F, Onn A, Felip E, Tabernero J, Batist G, Kurzrock R, Rubin E, Schilsky RL. Lazar V, et al. Among authors: wunder f. Ther Adv Med Oncol. 2023 Mar 31;15:17588359231156382. doi: 10.1177/17588359231156382. eCollection 2023. Ther Adv Med Oncol. 2023. PMID: 37025260 Free PMC article.
BAY-6096: A Potent, Selective, and Highly Water-Soluble Adrenergic α2B Antagonist.
Meibom D, Meyer J, von Buehler CJ, Collins KD, Maassen S, Gericke KM, Hüser J, Mittendorf J, Ortega Hernandez N, Schamberger J, Stampfuss J, Straub A, Torge A, Witowski N, Wunder F. Meibom D, et al. Among authors: wunder f. J Med Chem. 2023 Apr 13;66(7):4659-4670. doi: 10.1021/acs.jmedchem.2c01690. Epub 2023 Mar 18. J Med Chem. 2023. PMID: 36932954 Free PMC article.
BAY-7081: A Potent, Selective, and Orally Bioavailable Cyanopyridone-Based PDE9A Inhibitor.
Meibom D, Micus S, Andreevski AL, Anlauf S, Bogner P, von Buehler CJ, Dieskau AP, Dreher J, Eitner F, Fliegner D, Follmann M, Gericke KM, Maassen S, Meyer J, Schlemmer KH, Steuber H, Tersteegen A, Wunder F. Meibom D, et al. Among authors: wunder f. J Med Chem. 2022 Dec 22;65(24):16420-16431. doi: 10.1021/acs.jmedchem.2c01267. Epub 2022 Dec 7. J Med Chem. 2022. PMID: 36475653 Free PMC article.
Comorbidity between lung cancer and COVID-19 pneumonia: role of immunoregulatory gene transcripts in high ACE2-expressing normal lung.
Lazar V, Raynaud J, Magidi S, Bresson C, Martini JF, Galbraith S, Wunder F, Onn A, Batist G, Girard N, Lassen U, Pramesh CS, Al-Omari A, Ikeda S, Berchem G, Blay JY, Solomon B, Felip E, Tabernero J, Rubin E, Philip T, Porgador A, Berindan-Neagoe I, Schilsky RL, Kurzrock R. Lazar V, et al. Among authors: wunder f. Ther Adv Med Oncol. 2022 Oct 28;14:17588359221133893. doi: 10.1177/17588359221133893. eCollection 2022. Ther Adv Med Oncol. 2022. PMID: 36324736 Free PMC article.
Inhaled mosliciguat (BAY 1237592): targeting pulmonary vasculature via activating apo-sGC.
Becker-Pelster EM, Hahn MG, Delbeck M, Dietz L, Hüser J, Kopf J, Kraemer T, Marquardt T, Mondritzki T, Nagelschmitz J, Nikkho SM, Pires PV, Tinel H, Weimann G, Wunder F, Sandner P, Schuhmacher J, Stasch JP, Truebel HKF. Becker-Pelster EM, et al. Among authors: wunder f. Respir Res. 2022 Oct 1;23(1):272. doi: 10.1186/s12931-022-02189-1. Respir Res. 2022. PMID: 36183104 Free PMC article.
A WIN Consortium phase I study exploring avelumab, palbociclib, and axitinib in advanced non-small cell lung cancer.
Solomon B, Callejo A, Bar J, Berchem G, Bazhenova L, Saintigny P, Wunder F, Raynaud J, Girard N, Lee JJ, Sulaiman R, Prouse B, Bresson C, Ventura H, Magidi S, Rubin E, Young B, Onn A, Leyland-Jones B, Schilsky RL, Lazar V, Felip E, Kurzrock R. Solomon B, et al. Among authors: wunder f. Cancer Med. 2022 Jul;11(14):2790-2800. doi: 10.1002/cam4.4635. Epub 2022 Mar 20. Cancer Med. 2022. PMID: 35307972 Free PMC article. Clinical Trial.
Establishment of a novel, cell-based autotaxin assay.
Dobersalske C, Grundmann M, Timmermann A, Theisen L, Kölling F, Harris RC, Fuerstner C, Becker MS, Wunder F. Dobersalske C, et al. Among authors: wunder f. Anal Biochem. 2021 Oct 1;630:114322. doi: 10.1016/j.ab.2021.114322. Epub 2021 Jul 31. Anal Biochem. 2021. PMID: 34343482
50 results