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Factor XII in coagulation, inflammation and beyond.
Didiasova M, Wujak L, Schaefer L, Wygrecka M. Didiasova M, et al. Among authors: wujak l. Cell Signal. 2018 Nov;51:257-265. doi: 10.1016/j.cellsig.2018.08.006. Epub 2018 Aug 15. Cell Signal. 2018. PMID: 30118759 Review.
TGF-β directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury.
Peters DM, Vadász I, Wujak L, Wygrecka M, Olschewski A, Becker C, Herold S, Papp R, Mayer K, Rummel S, Brandes RP, Günther A, Waldegger S, Eickelberg O, Seeger W, Morty RE. Peters DM, et al. Among authors: wujak l. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):E374-83. doi: 10.1073/pnas.1306798111. Epub 2013 Dec 9. Proc Natl Acad Sci U S A. 2014. PMID: 24324142 Free PMC article.
Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury.
Wygrecka M, Kosanovic D, Wujak L, Reppe K, Henneke I, Frey H, Didiasova M, Kwapiszewska G, Marsh LM, Baal N, Hackstein H, Zakrzewicz D, Müller-Redetzky HC, de Maat S, Maas C, Nolte MW, Panousis C, Schermuly RT, Seeger W, Witzenrath M, Schaefer L, Markart P. Wygrecka M, et al. Among authors: wujak l. Am J Respir Crit Care Med. 2017 Jul 15;196(2):186-199. doi: 10.1164/rccm.201604-0712OC. Am J Respir Crit Care Med. 2017. PMID: 28005404
Pirfenidone exerts antifibrotic effects through inhibition of GLI transcription factors.
Didiasova M, Singh R, Wilhelm J, Kwapiszewska G, Wujak L, Zakrzewicz D, Schaefer L, Markart P, Seeger W, Lauth M, Wygrecka M. Didiasova M, et al. Among authors: wujak l. FASEB J. 2017 May;31(5):1916-1928. doi: 10.1096/fj.201600892RR. Epub 2017 Feb 1. FASEB J. 2017. PMID: 28148565
Because GLI transcription factors are not only crucial for Hh-mediated changes but are also required as mediators of TGF-beta signaling, our findings suggest that pirfenidone exerts its clinically beneficial effects through dual Hh/TGF-beta inhibition by targeting the GLI2 protei …
Because GLI transcription factors are not only crucial for Hh-mediated changes but are also required as mediators of TGF-beta signaling, our …
FXII promotes proteolytic processing of the LRP1 ectodomain.
Wujak L, Hesse C, Sewald K, Jonigk D, Braubach P, Warnecke G, Fieguth HG, Braun A, Lochnit G, Markart P, Schaefer L, Wygrecka M. Wujak L, et al. Biochim Biophys Acta Gen Subj. 2017 Aug;1861(8):2088-2098. doi: 10.1016/j.bbagen.2017.05.023. Epub 2017 May 25. Biochim Biophys Acta Gen Subj. 2017. PMID: 28552561
Coagulation factor XII regulates inflammatory responses in human lungs.
Hess R, Wujak L, Hesse C, Sewald K, Jonigk D, Warnecke G, Fieguth HG, de Maat S, Maas C, Bonella F, Preissner KT, Weiss B, Schaefer L, Kuebler WM, Markart P, Wygrecka M. Hess R, et al. Among authors: wujak l. Thromb Haemost. 2017 Oct 5;117(10):1896-1907. doi: 10.1160/TH16-12-0904. Epub 2017 Aug 17. Thromb Haemost. 2017. PMID: 28816340
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