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Combined HIV-1 sequence and integration site analysis informs viral dynamics and allows reconstruction of replicating viral ancestors.
Patro SC, Brandt LD, Bale MJ, Halvas EK, Joseph KW, Shao W, Wu X, Guo S, Murrell B, Wiegand A, Spindler J, Raley C, Hautman C, Sobolewski M, Fennessey CM, Hu WS, Luke B, Hasson JM, Niyongabo A, Capoferri AA, Keele BF, Milush J, Hoh R, Deeks SG, Maldarelli F, Hughes SH, Coffin JM, Rausch JW, Mellors JW, Kearney MF. Patro SC, et al. Among authors: wu x. Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25891-25899. doi: 10.1073/pnas.1910334116. Epub 2019 Nov 27. Proc Natl Acad Sci U S A. 2019. PMID: 31776247 Free PMC article.
Redefining the common insertion site.
Wu X, Luke BT, Burgess SM. Wu X, et al. Virology. 2006 Jan 20;344(2):292-5. doi: 10.1016/j.virol.2005.08.047. Epub 2005 Nov 4. Virology. 2006. PMID: 16271739 Free article.
Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration.
Ferris AL, Wu X, Hughes CM, Stewart C, Smith SJ, Milne TA, Wang GG, Shun MC, Allis CD, Engelman A, Hughes SH. Ferris AL, et al. Among authors: wu x. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3135-40. doi: 10.1073/pnas.0914142107. Epub 2010 Feb 1. Proc Natl Acad Sci U S A. 2010. PMID: 20133638 Free PMC article.
Long-range enhancers on 8q24 regulate c-Myc.
Sotelo J, Esposito D, Duhagon MA, Banfield K, Mehalko J, Liao H, Stephens RM, Harris TJ, Munroe DJ, Wu X. Sotelo J, et al. Among authors: wu x. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3001-5. doi: 10.1073/pnas.0906067107. Epub 2010 Jan 26. Proc Natl Acad Sci U S A. 2010. PMID: 20133699 Free PMC article.
HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.
Wang H, Jurado KA, Wu X, Shun MC, Li X, Ferris AL, Smith SJ, Patel PA, Fuchs JR, Cherepanov P, Kvaratskhelia M, Hughes SH, Engelman A. Wang H, et al. Among authors: wu x. Nucleic Acids Res. 2012 Dec;40(22):11518-30. doi: 10.1093/nar/gks913. Epub 2012 Oct 5. Nucleic Acids Res. 2012. PMID: 23042676 Free PMC article.
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