Wu JS - Search Results

1

Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists.

Peng YH, Coumar MS, Leou JS, Wu JS, Shiao HY, Lin CH, Lin WH, Lien TW, Chen X, Hsu JT, Chao YS, Huang CF, Lyu PC, Hsieh HP, Wu SY. Peng YH, et al. Among authors: wu js, wu sy. ChemMedChem. 2010 Oct 4;5(10):1707-16. doi: 10.1002/cmdc.201000194. ChemMedChem. 2010. PMID: 20734309

2

Structure-based drug design of novel Aurora kinase A inhibitors: structural basis for potency and specificity.

Coumar MS, Leou JS, Shukla P, Wu JS, Dixit AK, Lin WH, Chang CY, Lien TW, Tan UK, Chen CH, Hsu JT, Chao YS, Wu SY, Hsieh HP. Coumar MS, et al. Among authors: wu js, wu sy. J Med Chem. 2009 Feb 26;52(4):1050-62. doi: 10.1021/jm801270e. J Med Chem. 2009. PMID: 19140666

3

Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists.

Lin CH, Peng YH, Coumar MS, Chittimalla SK, Liao CC, Lyn PC, Huang CC, Lien TW, Lin WH, Hsu JT, Cheng JH, Chen X, Wu JS, Chao YS, Lee HJ, Juo CG, Wu SY, Hsieh HP. Lin CH, et al. Among authors: wu js, wu sy. J Med Chem. 2009 Apr 23;52(8):2618-22. doi: 10.1021/jm801594x. J Med Chem. 2009. PMID: 19301897

4

Identification, SAR studies, and X-ray co-crystallographic analysis of a novel furanopyrimidine aurora kinase A inhibitor.

Coumar MS, Tsai MT, Chu CY, Uang BJ, Lin WH, Chang CY, Chang TY, Leou JS, Teng CH, Wu JS, Fang MY, Chen CH, Hsu JT, Wu SY, Chao YS, Hsieh HP. Coumar MS, et al. Among authors: wu js, wu sy. ChemMedChem. 2010 Feb 1;5(2):255-67. doi: 10.1002/cmdc.200900339. ChemMedChem. 2010. PMID: 20039358

5

Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: the role of the DFG motif in the design of epidermal growth factor receptor inhibitors.

Peng YH, Shiao HY, Tu CH, Liu PM, Hsu JT, Amancha PK, Wu JS, Coumar MS, Chen CH, Wang SY, Lin WH, Sun HY, Chao YS, Lyu PC, Hsieh HP, Wu SY. Peng YH, et al. Among authors: wu js, wu sy. J Med Chem. 2013 May 23;56(10):3889-903. doi: 10.1021/jm400072p. Epub 2013 May 10. J Med Chem. 2013. PMID: 23611691

6

Aurora kinase A inhibitors: identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold.

Coumar MS, Wu JS, Leou JS, Tan UK, Chang CY, Chang TY, Lin WH, Hsu JT, Chao YS, Wu SY, Hsieh HP. Coumar MS, et al. Among authors: wu js, wu sy. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1623-7. doi: 10.1016/j.bmcl.2008.01.068. Epub 2008 Jan 19. Bioorg Med Chem Lett. 2008. PMID: 18243698

7

Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identification.

Coumar MS, Chu CY, Lin CW, Shiao HY, Ho YL, Reddy R, Lin WH, Chen CH, Peng YH, Leou JS, Lien TW, Huang CT, Fang MY, Wu SH, Wu JS, Chittimalla SK, Song JS, Hsu JT, Wu SY, Liao CC, Chao YS, Hsieh HP. Coumar MS, et al. Among authors: wu sh, wu js, wu sy. J Med Chem. 2010 Jul 8;53(13):4980-8. doi: 10.1021/jm1000198. J Med Chem. 2010. PMID: 20550212

8

Discovery of non-glycoside sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors by ligand-based virtual screening.

Wu JS, Peng YH, Wu JM, Hsieh CJ, Wu SH, Coumar MS, Song JS, Lee JC, Tsai CH, Chen CT, Liu YW, Chao YS, Wu SY. Wu JS, et al. Among authors: wu sh, wu jm, wu sy. J Med Chem. 2010 Dec 23;53(24):8770-4. doi: 10.1021/jm101080v. Epub 2010 Nov 19. J Med Chem. 2010. PMID: 21090651

9

Scaffold-hopping strategy: synthesis and biological evaluation of 5,6-fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents.

Tung YS, Coumar MS, Wu YS, Shiao HY, Chang JY, Liou JP, Shukla P, Chang CW, Chang CY, Kuo CC, Yeh TK, Lin CY, Wu JS, Wu SY, Liao CC, Hsieh HP. Tung YS, et al. Among authors: wu js, wu sy, wu ys. J Med Chem. 2011 Apr 28;54(8):3076-80. doi: 10.1021/jm101027s. Epub 2011 Mar 24. J Med Chem. 2011. PMID: 21434659

10

Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules.

Wu JM, Chen CT, Coumar MS, Lin WH, Chen ZJ, Hsu JT, Peng YH, Shiao HY, Lin WH, Chu CY, Wu JS, Lin CT, Chen CP, Hsueh CC, Chang KY, Kao LP, Huang CY, Chao YS, Wu SY, Hsieh HP, Chi YH. Wu JM, et al. Among authors: wu js, wu sy. Proc Natl Acad Sci U S A. 2013 May 7;110(19):E1779-87. doi: 10.1073/pnas.1220523110. Epub 2013 Apr 22. Proc Natl Acad Sci U S A. 2013. PMID: 23610398 Free PMC article.

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