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The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis.
Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Prodhomme T, Duong B, Whang MI, Advincula R, Agelidis A, Barrera J, Wu H, Burlingame A, Malynn BA, Zamvil SS, Ma A. Onizawa M, et al. Among authors: wu h. Nat Immunol. 2015 Jun;16(6):618-27. doi: 10.1038/ni.3172. Epub 2015 May 4. Nat Immunol. 2015. PMID: 25939025 Free PMC article.
Cryo-EM structure of the gasdermin A3 membrane pore.
Ruan J, Xia S, Liu X, Lieberman J, Wu H. Ruan J, et al. Among authors: wu h. Nature. 2018 May;557(7703):62-67. doi: 10.1038/s41586-018-0058-6. Epub 2018 Apr 25. Nature. 2018. PMID: 29695864 Free PMC article.
SERPINB1-mediated checkpoint of inflammatory caspase activation.
Choi YJ, Kim S, Choi Y, Nielsen TB, Yan J, Lu A, Ruan J, Lee HR, Wu H, Spellberg B, Jung JU. Choi YJ, et al. Among authors: wu h. Nat Immunol. 2019 Mar;20(3):276-287. doi: 10.1038/s41590-018-0303-z. Epub 2019 Jan 28. Nat Immunol. 2019. PMID: 30692621 Free PMC article.
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