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Hardwiring tissue-specific AAV transduction in mice through engineered receptor expression.
Zengel J, Wang YX, Seo JW, Ning K, Hamilton JN, Wu B, Raie M, Holbrook C, Su S, Clements DR, Pillay S, Puschnik AS, Winslow MM, Idoyaga J, Nagamine CM, Sun Y, Mahajan VB, Ferrara KW, Blau HM, Carette JE. Zengel J, et al. Among authors: wu b. Nat Methods. 2023 Jul;20(7):1070-1081. doi: 10.1038/s41592-023-01896-x. Epub 2023 Jun 8. Nat Methods. 2023. PMID: 37291262 Free PMC article.
Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation.
Seo JW, Ingham ES, Mahakian L, Tumbale S, Wu B, Aghevlian S, Shams S, Baikoghli M, Jain P, Ding X, Goeden N, Dobreva T, Flytzanis NC, Chavez M, Singhal K, Leib R, James ML, Segal DJ, Cheng RH, Silva EA, Gradinaru V, Ferrara KW. Seo JW, et al. Among authors: wu b. Nat Commun. 2020 Apr 30;11(1):2102. doi: 10.1038/s41467-020-15818-4. Nat Commun. 2020. PMID: 32355221 Free PMC article.
Low-frequency ultrasound-mediated cytokine transfection enhances T cell recruitment at local and distant tumor sites.
Ilovitsh T, Feng Y, Foiret J, Kheirolomoom A, Zhang H, Ingham ES, Ilovitsh A, Tumbale SK, Fite BZ, Wu B, Raie MN, Zhang N, Kare AJ, Chavez M, Qi LS, Pelled G, Gazit D, Vermesh O, Steinberg I, Gambhir SS, Ferrara KW. Ilovitsh T, et al. Among authors: wu b. Proc Natl Acad Sci U S A. 2020 Jun 9;117(23):12674-12685. doi: 10.1073/pnas.1914906117. Epub 2020 May 19. Proc Natl Acad Sci U S A. 2020. PMID: 32430322 Free PMC article.
Development of thermosensitive resiquimod-loaded liposomes for enhanced cancer immunotherapy.
Zhang H, Tang WL, Kheirolomoom A, Fite BZ, Wu B, Lau K, Baikoghli M, Raie MN, Tumbale SK, Foiret J, Ingham ES, Mahakian LM, Tam SM, Cheng RH, Borowsky AD, Ferrara KW. Zhang H, et al. Among authors: wu b. J Control Release. 2021 Feb 10;330:1080-1094. doi: 10.1016/j.jconrel.2020.11.013. Epub 2020 Nov 13. J Control Release. 2021. PMID: 33189786 Free PMC article.
Systemic Immunotherapy with Micellar Resiquimod-Polymer Conjugates Triggers a Robust Antitumor Response in a Breast Cancer Model.
Kakwere H, Zhang H, Ingham ES, Nura-Raie M, Tumbale SK, Allen R, Tam SM, Wu B, Liu C, Kheirolomoom A, Fite BZ, Ilovitsh A, Lewis JS, Ferrara KW. Kakwere H, et al. Among authors: wu b. Adv Healthc Mater. 2021 May;10(10):e2100008. doi: 10.1002/adhm.202100008. Epub 2021 Mar 1. Adv Healthc Mater. 2021. PMID: 33646600 Free PMC article.
In situ T-cell transfection by anti-CD3-conjugated lipid nanoparticles leads to T-cell activation, migration, and phenotypic shift.
Kheirolomoom A, Kare AJ, Ingham ES, Paulmurugan R, Robinson ER, Baikoghli M, Inayathullah M, Seo JW, Wang J, Fite BZ, Wu B, Tumbale SK, Raie MN, Cheng RH, Nichols L, Borowsky AD, Ferrara KW. Kheirolomoom A, et al. Among authors: wu b. Biomaterials. 2022 Feb;281:121339. doi: 10.1016/j.biomaterials.2021.121339. Epub 2021 Dec 29. Biomaterials. 2022. PMID: 35078042 Free PMC article.
Multimodal imaging of capsid and cargo reveals differential brain targeting and liver detargeting of systemically-administered AAVs.
Seo JW, Ajenjo J, Wu B, Robinson E, Raie MN, Wang J, Tumbale SK, Buccino P, Anders DA, Shen B, Habte FG, Beinat C, James ML, Reyes ST, Ravindra Kumar S, Miles TF, Lee JT, Gradinaru V, Ferrara KW. Seo JW, et al. Among authors: wu b. Biomaterials. 2022 Sep;288:121701. doi: 10.1016/j.biomaterials.2022.121701. Epub 2022 Aug 6. Biomaterials. 2022. PMID: 35985893 Free PMC article.
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