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Mendelian neurodegenerative disease genes involved in autophagy.
Stamatakou E, Wróbel L, Hill SM, Puri C, Son SM, Fujimaki M, Zhu Y, Siddiqi F, Fernandez-Estevez M, Manni MM, Park SJ, Villeneuve J, Rubinsztein DC. Stamatakou E, et al. Among authors: wrobel l. Cell Discov. 2020 May 5;6:24. doi: 10.1038/s41421-020-0158-y. eCollection 2020. Cell Discov. 2020. PMID: 32377374 Free PMC article. Review.
VCP/p97 regulates Beclin-1-dependent autophagy initiation.
Hill SM, Wrobel L, Ashkenazi A, Fernandez-Estevez M, Tan K, Bürli RW, Rubinsztein DC. Hill SM, et al. Among authors: wrobel l. Nat Chem Biol. 2021 Apr;17(4):448-455. doi: 10.1038/s41589-020-00726-x. Epub 2021 Jan 28. Nat Chem Biol. 2021. PMID: 33510452
The different autophagy degradation pathways and neurodegeneration.
Fleming A, Bourdenx M, Fujimaki M, Karabiyik C, Krause GJ, Lopez A, Martín-Segura A, Puri C, Scrivo A, Skidmore J, Son SM, Stamatakou E, Wrobel L, Zhu Y, Cuervo AM, Rubinsztein DC. Fleming A, et al. Among authors: wrobel l. Neuron. 2022 Mar 16;110(6):935-966. doi: 10.1016/j.neuron.2022.01.017. Epub 2022 Feb 7. Neuron. 2022. PMID: 35134347 Free PMC article. Review.
Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance.
Wrobel L, Hill SM, Djajadikerta A, Fernandez-Estevez M, Karabiyik C, Ashkenazi A, Barratt VJ, Stamatakou E, Gunnarsson A, Rasmusson T, Miele EW, Beaton N, Bruderer R, Feng Y, Reiter L, Castaldi MP, Jarvis R, Tan K, Bürli RW, Rubinsztein DC. Wrobel L, et al. Nat Commun. 2022 Jul 16;13(1):4146. doi: 10.1038/s41467-022-31905-0. Nat Commun. 2022. PMID: 35842429 Free PMC article.
70 results