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Spike-Dependent Opsonization Indicates Both Dose-Dependent Inhibition of Phagocytosis and That Non-Neutralizing Antibodies Can Confer Protection to SARS-CoV-2.
Bahnan W, Wrighton S, Sundwall M, Bläckberg A, Larsson O, Höglund U, Khakzad H, Godzwon M, Walle M, Elder E, Strand AS, Happonen L, André O, Ahnlide JK, Hellmark T, Wendel-Hansen V, Wallin RP, Malmstöm J, Malmström L, Ohlin M, Rasmussen M, Nordenfelt P. Bahnan W, et al. Among authors: wrighton s. Front Immunol. 2022 Jan 14;12:808932. doi: 10.3389/fimmu.2021.808932. eCollection 2021. Front Immunol. 2022. PMID: 35095897 Free PMC article.
Subclass-switched anti-spike IgG3 oligoclonal cocktails strongly enhance Fc-mediated opsonization.
Izadi A, Hailu A, Godzwon M, Wrighton S, Olofsson B, Schmidt T, Söderlund-Strand A, Elder E, Appelberg S, Valsjö M, Larsson O, Wendel-Hansen V, Ohlin M, Bahnan W, Nordenfelt P. Izadi A, et al. Among authors: wrighton s. Proc Natl Acad Sci U S A. 2023 Apr 11;120(15):e2217590120. doi: 10.1073/pnas.2217590120. Epub 2023 Apr 3. Proc Natl Acad Sci U S A. 2023. PMID: 37011197 Free PMC article.
A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein mediates immune function.
Bahnan W, Happonen L, Khakzad H, Kumra Ahnlide V, de Neergaard T, Wrighton S, André O, Bratanis E, Tang D, Hellmark T, Björck L, Shannon O, Malmström L, Malmström J, Nordenfelt P. Bahnan W, et al. Among authors: wrighton s. EMBO Mol Med. 2023 Feb 8;15(2):e16208. doi: 10.15252/emmm.202216208. Epub 2022 Dec 12. EMBO Mol Med. 2023. PMID: 36507602 Free PMC article.
The hinge-engineered IgG1-IgG3 hybrid subclass IgGh47 potently enhances Fc-mediated function of anti-streptococcal and SARS-CoV-2 antibodies.
Izadi A, Karami Y, Bratanis E, Wrighton S, Khakzad H, Nyblom M, Olofsson B, Happonen L, Tang D, Sundwall M, Godzwon M, Chao Y, Toledo AG, Schmidt T, Ohlin M, Nilges M, Malmström J, Bahnan W, Shannon O, Malmström L, Nordenfelt P. Izadi A, et al. Among authors: wrighton s. Nat Commun. 2024 Apr 27;15(1):3600. doi: 10.1038/s41467-024-47928-8. Nat Commun. 2024. PMID: 38678029 Free PMC article.
Immune evasion by proteolytic shedding of natural killer group 2, member D ligands in Helicobacter pylori infection.
Anthofer M, Windisch M, Haller R, Ehmann S, Wrighton S, Miller M, Schernthanner L, Kufferath I, Schauer S, Jelušić B, Kienesberger S, Zechner EL, Posselt G, Vales-Gomez M, Reyburn HT, Gorkiewicz G. Anthofer M, et al. Among authors: wrighton s. Front Immunol. 2024 Jan 22;15:1282680. doi: 10.3389/fimmu.2024.1282680. eCollection 2024. Front Immunol. 2024. PMID: 38318189 Free PMC article.
191 results