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Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling.
Adams R, Burnley RJ, Valenzano CR, Qureshi O, Doyle C, Lumb S, Del Carmen Lopez M, Griffin R, McMillan D, Taylor RD, Meier C, Mori P, Griffin LM, Wernery U, Kinne J, Rapecki S, Baker TS, Lawson AD, Wright M, Ettorre A. Adams R, et al. Among authors: wright m. Sci Rep. 2017 Jan 30;7:37716. doi: 10.1038/srep37716. Sci Rep. 2017. PMID: 28134246 Free PMC article.
The rapid generation of recombinant functional monoclonal antibodies from individual, antigen-specific bone marrow-derived plasma cells isolated using a novel fluorescence-based method.
Clargo AM, Hudson AR, Ndlovu W, Wootton RJ, Cremin LA, O'Dowd VL, Nowosad CR, Starkie DO, Shaw SP, Compson JE, White DP, MacKenzie B, Snowden JR, Newnham LE, Wright M, Stephens PE, Griffiths MR, Lawson AD, Lightwood DJ. Clargo AM, et al. Among authors: wright m. MAbs. 2014 Jan-Feb;6(1):143-59. doi: 10.4161/mabs.27044. MAbs. 2014. PMID: 24423622 Free PMC article.
Human immunoglobulin E flexes between acutely bent and extended conformations.
Drinkwater N, Cossins B, Keeble AH, Wright M, Cain K, Hailu H, Oxbrow A, Delgado J, Shuttleworth LK, Kao MW, McDonnell JM, Beavil AJ, Henry AJ, Sutton BJ. Drinkwater N, et al. Among authors: wright m. Nat Struct Mol Biol. 2014 Apr;21(4):397-404. doi: 10.1038/nsmb.2795. Epub 2014 Mar 16. Nat Struct Mol Biol. 2014. PMID: 24632569 Free PMC article.
Structurally Mapping Antibody Repertoires.
Krawczyk K, Kelm S, Kovaltsuk A, Galson JD, Kelly D, Trück J, Regep C, Leem J, Wong WK, Nowak J, Snowden J, Wright M, Starkie L, Scott-Tucker A, Shi J, Deane CM. Krawczyk K, et al. Among authors: wright m. Front Immunol. 2018 Jul 23;9:1698. doi: 10.3389/fimmu.2018.01698. eCollection 2018. Front Immunol. 2018. PMID: 30083160 Free PMC article.
4,453 results