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Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and Cancer.
Abacha YZ, Forkuo AD, Gbedema SY, Mittal N, Ottilie S, Rocamora F, Winzeler EA, van Schalkwyk DA, Kelly JM, Taylor MC, Reader J, Birkholtz LM, Lisgarten DR, Cockcroft JK, Lisgarten JN, Palmer RA, Talbert RC, Shnyder SD, Wright CW. Abacha YZ, et al. Among authors: wright cw. Front Pharmacol. 2022 Apr 26;13:875647. doi: 10.3389/fphar.2022.875647. eCollection 2022. Front Pharmacol. 2022. PMID: 35600849 Free PMC article.
Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity.
Sola I, Castellà S, Viayna E, Galdeano C, Taylor MC, Gbedema SY, Pérez B, Clos MV, Jones DC, Fairlamb AH, Wright CW, Kelly JM, Muñoz-Torrero D. Sola I, et al. Among authors: wright cw. Bioorg Med Chem. 2015 Aug 15;23(16):5156-67. doi: 10.1016/j.bmc.2015.01.031. Epub 2015 Jan 24. Bioorg Med Chem. 2015. PMID: 25678015
Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents.
Sola I, Artigas A, Taylor MC, Pérez-Areales FJ, Viayna E, Clos MV, Pérez B, Wright CW, Kelly JM, Muñoz-Torrero D. Sola I, et al. Among authors: wright cw. Bioorg Med Chem. 2016 Nov 1;24(21):5162-5171. doi: 10.1016/j.bmc.2016.08.036. Epub 2016 Aug 22. Bioorg Med Chem. 2016. PMID: 27591008 Free PMC article.
147 results