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A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration.
San Gil R, Pascovici D, Venturato J, Brown-Wright H, Mehta P, Madrid San Martin L, Wu J, Luan W, Chui YK, Bademosi AT, Swaminathan S, Naidoo S, Berning BA, Wright AL, Keating SS, Curtis MA, Faull RLM, Lee JD, Ngo ST, Lee A, Morsch M, Chung RS, Scotter E, Lisowski L, Mirzaei M, Walker AK. San Gil R, et al. Among authors: wright al. Nat Commun. 2024 Feb 19;15(1):1508. doi: 10.1038/s41467-024-45646-9. Nat Commun. 2024. PMID: 38374041 Free PMC article.
Splicing factor proline and glutamine rich intron retention, reduced expression and aggregate formation are pathological features of amyotrophic lateral sclerosis.
Hogan AL, Grima N, Fifita JA, McCann EP, Heng B, Fat SCM, Wu S, Maharjan R, Cain AK, Henden L, Rayner S, Tarr I, Zhang KY, Zhao Q, Zhang ZH, Wright A, Lee A, Morsch M, Yang S, Williams KL, Blair IP. Hogan AL, et al. Among authors: wright a. Neuropathol Appl Neurobiol. 2021 Dec;47(7):990-1003. doi: 10.1111/nan.12749. Epub 2021 Aug 2. Neuropathol Appl Neurobiol. 2021. PMID: 34288034
Riluzole does not ameliorate disease caused by cytoplasmic TDP-43 in a mouse model of amyotrophic lateral sclerosis.
Wright AL, Della Gatta PA, Le S, Berning BA, Mehta P, Jacobs KR, Gul H, San Gil R, Hedl TJ, Riddell WR, Watson O, Keating SS, Venturato J, Chung RS, Atkin JD, Lee A, Shi B, Blizzard CA, Morsch M, Walker AK. Wright AL, et al. Eur J Neurosci. 2021 Sep;54(6):6237-6255. doi: 10.1111/ejn.15422. Epub 2021 Aug 26. Eur J Neurosci. 2021. PMID: 34390052
Spermidine treatment: induction of autophagy but also apoptosis?
Watchon M, Wright AL, Ahel HI, Robinson KJ, Plenderleith SK, Kuriakose A, Yuan KC, Laird AS. Watchon M, et al. Among authors: wright al. Mol Brain. 2024 Mar 5;17(1):15. doi: 10.1186/s13041-024-01085-7. Mol Brain. 2024. PMID: 38443995 Free PMC article.
A new mouse line with reduced GluA2 Q/R site RNA editing exhibits loss of dendritic spines, hippocampal CA1-neuron loss, learning and memory impairments and NMDA receptor-independent seizure vulnerability.
Konen LM, Wright AL, Royle GA, Morris GP, Lau BK, Seow PW, Zinn R, Milham LT, Vaughan CW, Vissel B. Konen LM, et al. Among authors: wright al. Mol Brain. 2020 Feb 27;13(1):27. doi: 10.1186/s13041-020-0545-1. Mol Brain. 2020. PMID: 32102661 Free PMC article.
The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer's disease.
Wright AL, Konen LM, Mockett BG, Morris GP, Singh A, Burbano LE, Milham L, Hoang M, Zinn R, Chesworth R, Tan RP, Royle GA, Clark I, Petrou S, Abraham WC, Vissel B. Wright AL, et al. Mol Neurodegener. 2023 Sep 28;18(1):65. doi: 10.1186/s13024-023-00632-5. Mol Neurodegener. 2023. PMID: 37759260 Free PMC article.
271 results