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Page 1
Discovery of orally bioavailable 1,3,4-trisubstituted 2-oxopiperazine-based melanocortin-4 receptor agonists as potential antiobesity agents.
Tian X, Switzer AG, Derose SA, Mishra RK, Solinsky MG, Mumin RN, Ebetino FH, Jayasinghe LR, Webster ME, Colson AO, Crossdoersen D, Pinney BB, Farmer JA, Dowty ME, Obringer CM, Cruze CA, Burklow ML, Suchanek PM, Dong L, Dirr MK, Sheldon RJ, Wos JA. Tian X, et al. Among authors: wos ja. J Med Chem. 2008 Oct 9;51(19):6055-66. doi: 10.1021/jm800525p. Epub 2008 Sep 5. J Med Chem. 2008. PMID: 18771254
The efficacy and cardiac evaluation of aminomethyl tetrahydronaphthalene ketopiperazines: a novel class of potent MCH-R1 antagonists.
Méndez-Andino JL, Colson AO, Meyers KM, Mitchell MC, Hodge K, Howard JM, Kim N, Ackley DC, Holbert JK, Mittelstadt SW, Dowty ME, Obringer CM, Suchanek P, Reizes O, Hu XE, Wos JA. Méndez-Andino JL, et al. Among authors: wos ja. Bioorg Med Chem. 2007 Mar 1;15(5):2092-105. doi: 10.1016/j.bmc.2006.12.028. Epub 2006 Dec 20. Bioorg Med Chem. 2007. PMID: 17236777
Novel pyrazolopiperazinone- and pyrrolopiperazinone-based MCH-R1 antagonists.
Meyers KM, Méndez-Andino J, Colson AO, Hu XE, Wos JA, Mitchell MC, Hodge K, Howard J, Paris JL, Dowty ME, Obringer CM, Reizes O. Meyers KM, et al. Among authors: wos ja. Bioorg Med Chem Lett. 2007 Feb 1;17(3):657-61. doi: 10.1016/j.bmcl.2006.10.096. Epub 2006 Nov 6. Bioorg Med Chem Lett. 2007. PMID: 17174091
Synthesis and evaluation of unsaturated caprolactams as interleukin-1beta converting enzyme (ICE) inhibitors.
Wang Y, O'Neil SV, Wos JA, Oppong KA, Laufersweiler MC, Soper DL, Ellis CD, Baize MW, Fancher AN, Lu W, Suchanek MK, Wang RL, Schwecke WP, Cruze CA, Buchalova M, Belkin M, De B, Demuth TP Jr. Wang Y, et al. Among authors: wos ja. Bioorg Med Chem. 2007 Feb 1;15(3):1311-22. doi: 10.1016/j.bmc.2006.11.011. Epub 2006 Nov 10. Bioorg Med Chem. 2007. PMID: 17127070
Aminomethyl tetrahydronaphthalene ketopiperazine MCH-R1 antagonists--Increasing selectivity over hERG.
Meyers KM, Méndez-Andino JL, Colson AO, Warshakoon NC, Wos JA, Mitchell MC, Hodge KM, Howard JM, Ackley DC, Holbert JK, Mittelstadt SW, Dowty ME, Obringer CM, Reizes O, Hu XE. Meyers KM, et al. Among authors: wos ja. Bioorg Med Chem Lett. 2007 Feb 1;17(3):819-22. doi: 10.1016/j.bmcl.2006.10.052. Epub 2006 Oct 25. Bioorg Med Chem Lett. 2007. PMID: 17107796
Synthesis and evaluation of novel 8,5-fused bicyclic peptidomimetic compounds as interleukin-1beta converting enzyme (ICE) inhibitors.
Soper DL, Sheville JX, O'Neil SV, Wang Y, Laufersweiler MC, Oppong KA, Wos JA, Ellis CD, Baize MW, Chen JJ, Fancher AN, Lu W, Suchanek MK, Wang RL, Schwecke WP, Cruze CA, Buchalova M, Belkin M, Wireko F, Ritter A, De B, Wang D, Demuth TP Jr. Soper DL, et al. Among authors: wos ja. Bioorg Med Chem. 2006 Dec 1;14(23):7880-92. doi: 10.1016/j.bmc.2006.07.056. Bioorg Med Chem. 2006. PMID: 16908171
27 results