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The SHDRA syndrome-associated gene TMEM260 encodes a protein-specific O-mannosyltransferase.
Larsen ISB, Povolo L, Zhou L, Tian W, Mygind KJ, Hintze J, Jiang C, Hartill V, Prescott K, Johnson CA, Mullegama SV, McConkie-Rosell A, McDonald M, Hansen L, Vakhrushev SY, Schjoldager KT, Clausen H, Worzfeld T, Joshi HJ, Halim A. Larsen ISB, et al. Among authors: worzfeld t. Proc Natl Acad Sci U S A. 2023 May 23;120(21):e2302584120. doi: 10.1073/pnas.2302584120. Epub 2023 May 15. Proc Natl Acad Sci U S A. 2023. PMID: 37186866 Free PMC article.
Genetic dissection of plexin signaling in vivo.
Worzfeld T, Swiercz JM, Sentürk A, Genz B, Korostylev A, Deng S, Xia J, Hoshino M, Epstein JA, Chan AM, Vollmar B, Acker-Palmer A, Kuner R, Offermanns S. Worzfeld T, et al. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2194-9. doi: 10.1073/pnas.1308418111. Epub 2014 Jan 27. Proc Natl Acad Sci U S A. 2014. PMID: 24469813 Free PMC article.
Mechanochemical control of epidermal stem cell divisions by B-plexins.
Jiang C, Javed A, Kaiser L, Nava MM, Xu R, Brandt DT, Zhao D, Mayer B, Fernández-Baldovinos J, Zhou L, Höß C, Sawmynaden K, Oleksy A, Matthews D, Weinstein LS, Hahn H, Gröne HJ, Graumann PL, Niessen CM, Offermanns S, Wickström SA, Worzfeld T. Jiang C, et al. Among authors: worzfeld t. Nat Commun. 2021 Feb 26;12(1):1308. doi: 10.1038/s41467-021-21513-9. Nat Commun. 2021. PMID: 33637728 Free PMC article.
Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair.
Xia J, Swiercz JM, Bañón-Rodríguez I, Matković I, Federico G, Sun T, Franz T, Brakebusch CH, Kumanogoh A, Friedel RH, Martín-Belmonte F, Gröne HJ, Offermanns S, Worzfeld T. Xia J, et al. Among authors: worzfeld t. Dev Cell. 2015 May 4;33(3):299-313. doi: 10.1016/j.devcel.2015.02.001. Epub 2015 Apr 16. Dev Cell. 2015. PMID: 25892012 Free article.
Plexin-B1 Mutation Drives Metastasis in Prostate Cancer Mouse Models.
Shorning B, Trent N, Griffiths DF, Worzfeld T, Offermanns S, Smalley MJ, Williamson M. Shorning B, et al. Among authors: worzfeld t. Cancer Res Commun. 2023 Mar 16;3(3):444-458. doi: 10.1158/2767-9764.CRC-22-0480. eCollection 2023 Mar. Cancer Res Commun. 2023. PMID: 36936664 Free PMC article.
An antagonistic monoclonal anti-Plexin-B1 antibody exerts therapeutic effects in mouse models of postmenopausal osteoporosis and multiple sclerosis.
Vogler M, Oleksy A, Schulze S, Fedorova M, Kojonazarov B, Nijjar S, Patel S, Jossi S, Sawmynaden K, Henry M, Brown R, Matthews D, Offermanns S, Worzfeld T. Vogler M, et al. Among authors: worzfeld t. J Biol Chem. 2022 Sep;298(9):102265. doi: 10.1016/j.jbc.2022.102265. Epub 2022 Jul 15. J Biol Chem. 2022. PMID: 35850304 Free PMC article.
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