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Page 1
Advancing translational research for colorectal immuno-oncology.
Thomas EM, Wright JA, Blake SJ, Page AJ, Worthley DL, Woods SL. Thomas EM, et al. Among authors: worthley dl. Br J Cancer. 2023 Oct;129(9):1442-1450. doi: 10.1038/s41416-023-02392-x. Epub 2023 Aug 10. Br J Cancer. 2023. PMID: 37563222 Free PMC article. Review.
Engineered bacteria detect tumor DNA.
Cooper RM, Wright JA, Ng JQ, Goyne JM, Suzuki N, Lee YK, Ichinose M, Radford G, Ryan FJ, Kumar S, Thomas EM, Vrbanac L, Knight R, Woods SL, Worthley DL, Hasty J. Cooper RM, et al. Among authors: worthley dl. Science. 2023 Aug 11;381(6658):682-686. doi: 10.1126/science.adf3974. Epub 2023 Aug 10. Science. 2023. PMID: 37561843 Free PMC article.
Loss of Grem1-lineage chondrogenic progenitor cells causes osteoarthritis.
Ng JQ, Jafarov TH, Little CB, Wang T, Ali AM, Ma Y, Radford GA, Vrbanac L, Ichinose M, Whittle S, Hunter DJ, Lannagan TRM, Suzuki N, Goyne JM, Kobayashi H, Wang TC, Haynes DR, Menicanin D, Gronthos S, Worthley DL, Woods SL, Mukherjee S. Ng JQ, et al. Among authors: worthley dl. Nat Commun. 2023 Oct 31;14(1):6909. doi: 10.1038/s41467-023-42199-1. Nat Commun. 2023. PMID: 37907525 Free PMC article.
Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia.
Gurbatri CR, Radford GA, Vrbanac L, Im J, Thomas EM, Coker C, Taylor SR, Jang Y, Sivan A, Rhee K, Saleh AA, Chien T, Zandkarimi F, Lia I, Lannagan TRM, Wang T, Wright JA, Kobayashi H, Ng JQ, Lawrence M, Sammour T, Thomas M, Lewis M, Papanicolas L, Perry J, Fitzsimmons T, Kaazan P, Lim A, Stavropoulos AM, Gouskos DA, Marker J, Ostroff C, Rogers G, Arpaia N, Worthley DL, Woods SL, Danino T. Gurbatri CR, et al. Among authors: worthley dl. Nat Commun. 2024 Jan 20;15(1):646. doi: 10.1038/s41467-024-44776-4. Nat Commun. 2024. PMID: 38245513 Free PMC article. Clinical Trial.
Impaired glycosylation of gastric mucins drives gastric tumorigenesis and serves as a novel therapeutic target.
Arai J, Hayakawa Y, Tateno H, Murakami K, Hayashi T, Hata M, Matsushita Y, Kinoshita H, Abe S, Kurokawa K, Oya Y, Tsuboi M, Ihara S, Niikura R, Suzuki N, Iwata Y, Shiokawa T, Shiomi C, Uekura C, Yamamoto K, Fujiwara H, Kawamura S, Nakagawa H, Mizuno S, Kudo T, Takahashi S, Ushiku T, Hirata Y, Fujii C, Nakayama J, Shibata S, Woods S, Worthley DL, Hatakeyama M, Wang TC, Fujishiro M. Arai J, et al. Among authors: worthley dl. Gastroenterology. 2024 Apr 5:S0016-5085(24)00363-9. doi: 10.1053/j.gastro.2024.03.037. Online ahead of print. Gastroenterology. 2024. PMID: 38583723
Colorectal cancer detection and treatment with engineered probiotics.
Gurbatri CR, Radford G, Vrbanac L, Coker C, Im JW, Taylor SR, Jang Y, Sivan A, Rhee K, Saleh AA, Chien T, Zandkarimi F, Lia I, Lannagan TR, Wang T, Wright JA, Thomas E, Kobayashi H, Ng JQ, Lawrence M, Sammour T, Thomas M, Lewis M, Papanicolas L, Perry J, Fitzsimmons T, Kaazan P, Lim A, Marker J, Ostroff C, Rogers G, Arpaia N, Worthley DL, Woods SL, Danino T. Gurbatri CR, et al. Among authors: worthley dl. bioRxiv [Preprint]. 2023 Apr 5:2023.04.03.535370. doi: 10.1101/2023.04.03.535370. bioRxiv. 2023. PMID: 37066243 Free PMC article. Preprint.
Loss of Grem1-articular cartilage progenitor cells causes osteoarthritis.
Ng JQ, Jafarov TH, Little CB, Wang T, Ali A, Ma Y, Radford GA, Vrbanac L, Ichinose M, Whittle S, Hunter D, Lannagan TR, Suzuki N, Goyne JM, Kobayashi H, Wang TC, Haynes D, Menicanin D, Gronthos S, Worthley DL, Woods SL, Mukherjee S. Ng JQ, et al. Among authors: worthley dl. bioRxiv [Preprint]. 2023 Mar 30:2023.03.29.534651. doi: 10.1101/2023.03.29.534651. bioRxiv. 2023. PMID: 37034712 Free PMC article. Preprint.
The Antianginal Drug Perhexiline Displays Cytotoxicity against Colorectal Cancer Cells In Vitro: A Potential for Drug Repurposing.
Dhakal B, Li CMY, Li R, Yeo K, Wright JA, Gieniec KA, Vrbanac L, Sammour T, Lawrence M, Thomas M, Lewis M, Perry J, Worthley DL, Woods SL, Drew P, Sallustio BC, Smith E, Horowitz JD, Maddern GJ, Licari G, Fenix K. Dhakal B, et al. Among authors: worthley dl. Cancers (Basel). 2022 Feb 18;14(4):1043. doi: 10.3390/cancers14041043. Cancers (Basel). 2022. PMID: 35205791 Free PMC article.
The Origin and Contribution of Cancer-Associated Fibroblasts in Colorectal Carcinogenesis.
Kobayashi H, Gieniec KA, Lannagan TRM, Wang T, Asai N, Mizutani Y, Iida T, Ando R, Thomas EM, Sakai A, Suzuki N, Ichinose M, Wright JA, Vrbanac L, Ng JQ, Goyne J, Radford G, Lawrence MJ, Sammour T, Hayakawa Y, Klebe S, Shin AE, Asfaha S, Bettington ML, Rieder F, Arpaia N, Danino T, Butler LM, Burt AD, Leedham SJ, Rustgi AK, Mukherjee S, Takahashi M, Wang TC, Enomoto A, Woods SL, Worthley DL. Kobayashi H, et al. Among authors: worthley dl. Gastroenterology. 2022 Mar;162(3):890-906. doi: 10.1053/j.gastro.2021.11.037. Epub 2021 Dec 6. Gastroenterology. 2022. PMID: 34883119 Free PMC article.
96 results