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From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization.
Nucleic Acids Res. 2022 Jul 8;50(12):6656-6670. doi: 10.1093/nar/gkac539.
Nucleic Acids Res. 2022.
PMID: 35736224
Free PMC article.
Synthesis, chirality-dependent conformational and biological properties of siRNAs containing 5'-(R)- and 5'-(S)-C-methyl-guanosine.
Mikami A, Erande N, Matsuda S, Kel'in A, Woods LB, Chickering T, Pallan PS, Schlegel MK, Zlatev I, Egli M, Manoharan M.
Mikami A, et al. Among authors: woods lb.
Nucleic Acids Res. 2020 Oct 9;48(18):10101-10124. doi: 10.1093/nar/gkaa750.
Nucleic Acids Res. 2020.
PMID: 32990754
Free PMC article.
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siRNAs containing 2'-fluorinated Northern-methanocarbacyclic (2'-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2'-F-NMC NTPs.
Akabane-Nakata M, Erande ND, Kumar P, Degaonkar R, Gilbert JA, Qin J, Mendez M, Woods LB, Jiang Y, Janas MM, O'Flaherty DK, Zlatev I, Schlegel MK, Matsuda S, Egli M, Manoharan M.
Akabane-Nakata M, et al. Among authors: woods lb.
Nucleic Acids Res. 2021 Mar 18;49(5):2435-2449. doi: 10.1093/nar/gkab050.
Nucleic Acids Res. 2021.
PMID: 33577685
Free PMC article.
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Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates.
Brown KM, Nair JK, Janas MM, Anglero-Rodriguez YI, Dang LTH, Peng H, Theile CS, Castellanos-Rizaldos E, Brown C, Foster D, Kurz J, Allen J, Maganti R, Li J, Matsuda S, Stricos M, Chickering T, Jung M, Wassarman K, Rollins J, Woods L, Kelin A, Guenther DC, Mobley MW, Petrulis J, McDougall R, Racie T, Bombardier J, Cha D, Agarwal S, Johnson L, Jiang Y, Lentini S, Gilbert J, Nguyen T, Chigas S, LeBlanc S, Poreci U, Kasper A, Rogers AB, Chong S, Davis W, Sutherland JE, Castoreno A, Milstein S, Schlegel MK, Zlatev I, Charisse K, Keating M, Manoharan M, Fitzgerald K, Wu JT, Maier MA, Jadhav V.
Brown KM, et al.
Nat Biotechnol. 2022 Oct;40(10):1500-1508. doi: 10.1038/s41587-022-01334-x. Epub 2022 Jun 2.
Nat Biotechnol. 2022.
PMID: 35654979
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Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs.
Matsuda S, Bala S, Liao JY, Datta D, Mikami A, Woods L, Harp JM, Gilbert JA, Bisbe A, Manoharan RM, Kim M, Theile CS, Guenther DC, Jiang Y, Agarwal S, Maganti R, Schlegel MK, Zlatev I, Charisse K, Rajeev KG, Castoreno A, Maier M, Janas MM, Egli M, Chaput JC, Manoharan M.
Matsuda S, et al.
J Am Chem Soc. 2023 Sep 13;145(36):19691-19706. doi: 10.1021/jacs.3c04744. Epub 2023 Aug 28.
J Am Chem Soc. 2023.
PMID: 37638886
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Effects of chlordecone and malnutrition on immune response in rats.
Chetty KN, Brown K, Walker J, Woods L.
Chetty KN, et al.
Life Sci. 1993;52(18):PL175-80. doi: 10.1016/0024-3205(93)90114-i.
Life Sci. 1993.
PMID: 7683362
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Platform for quantitative multiscale imaging of tissue composition.
Pinkert MA, Simmons ZJ, Niemeier RC, Dai B, Woods LB, Hall TJ, Campagnola PJ, Rogers JD, Eliceiri KW.
Pinkert MA, et al. Among authors: woods lb.
Biomed Opt Express. 2020 Mar 12;11(4):1927-1946. doi: 10.1364/BOE.383248. eCollection 2020 Apr 1.
Biomed Opt Express. 2020.
PMID: 32341858
Free PMC article.
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